Investigação da relação de marcadores moleculares nos genes TCF2L7, ADBR3 e FTO com os parâmetros bioquímicos e antropométricos
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Resumo
Objetivo: Selecionar e analisar de maneira sistemática, trabalhos nos quais a avaliação da correlação entre polimorfismos e medidas antropométricas e bioquímicas eram discutidas. Métodos: Trata-se de uma revisão integrativa, com base nas recomendações da Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) e utilizando da base de dados da PubMed com os SNPs, sendo possível inserir um SNP de interesse no campo de busca e ter acesso somente às publicações referentes a esse marcador genético específico, o período dos trabalhos pesquisados foi de 2017 a 2021. Resultados: Com base na estratégia de busca, foram identificados 96 trabalhos na plataforma PubMed, constatou-se que algumas alterações genéticas (mudança de base) podem influenciar no desenvolvimento de fenótipos associados a doenças como diabetes e obesidade, entre os trabalhos analisados, um exemplo foi os SNPs rs7901695 e rs12255372 no gene TCF7L2 com a transcrição encontrada para a regulação de glicose, resultando em uma suscetibilidade para DM2. Considerações finais: Fatores epigenéticos podem agir influenciando o fenótipo juntamente com os fatores genéticos, ademais, deve-se considerar a heterogeneidade genética e diferença entre as populações na investigação da associação de polimorfismos e expressão gênica associada a doenças não transmissíveis.
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