Gut microbiome and chronic kidney disease: an emerging relation
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Abstract
Objective: To assess the relationship between changes in the gut microbiome and the progression of chronic kidney disease (CKD), as well as the associated complications and potential therapeutic interventions targeting the gut microbiome that could be effective. Methods: This is an Integrative Review, carried out using the PubMed database platform, with the aim of locating relevant sources for the study. The search was carried out using the search strategy (("Gastrointestinal Microbiome"[MeSH]) OR (Gut Microbiome)) AND ("Renal Insufficiency, Chronic"[MeSH]) to find the articles, resulting in 309 initial articles. Of these, due to the inclusion and exclusion criteria, 20 became official sources. Results: The studies indicate that there is a close relationship between the intestinal microbiota and the progression of Chronic Kidney Disease, in which modulation of the gut-renal axis is a potential therapeutic target. Final considerations: The relationship between gut microbiota and CKD is clear, but more research is needed to clarify and confirm the hypotheses.
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