Microbioma intestinal e doença renal crônica: uma relação emergente
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Resumo
Objetivo: Avaliar a relação entre as alterações no microbioma intestinal e a progressão da doença renal crônica (DRC), bem como as complicações associadas e as potenciais intervenções terapêuticas voltadas ao microbioma intestinal que poderiam ser efetivas. Métodos: Trata-se de uma Revisão Integrativa, realizada por meio da plataforma de base de dados PubMed, com o intento de localizar fontes relevantes para o estudo. A pesquisa foi realizada através da estratégia de pesquisa (("Gastrointestinal Microbiome"[MeSH]) OR (Gut Microbiome)) AND ("Renal Insufficiency, Chronic"[MeSH]), para a busca dos artigos, resultando em 309 artigos iniciais. Dentre esses, devido aos critérios de inclusão e exclusão, 20 tornaram-se fontes oficiais. Resultados: Os estudos apontam que há uma estreita relação entre a microbiota intestinal e a progressão da Doença Renal Crônica, em que a modulação do eixo intestino-rim é um potencial alvo terapêutico. Considerações finais: A relação entre a microbiota intestinal e a DRC é evidente, porém, mais pesquisas na área são necessárias para esclarecimento e confirmação das hipóteses.
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