Prevalence, clinical aspects and treatment of depression in parkinson's disease
Article Sidebar
Main Article Content
Abstract
Objective: To assess the prevalence of depression in patients with Parkinson's disease, identify the clinical aspects of depression in this population and analyze the treatment options available. Methods: An integrative literature review was carried out using the Pubmed data platform in order to locate relevant sources. The following search terms were used: Depression; Depressive Disorder; and Parkinson's Disease, associated with Boolean operators in the following search strategy: ((Depression) OR ("Depressive Disorder"[MeSH])) AND ("Parkinson Disease"[MeSH]), resulting in 1241 initial articles. Within these, only 22 articles became official sources, according to inclusion and exclusion criteria. Results: The studies showed a strong relationship between Parkinson's Disease and Depression (even if underdiagnosed) and consequently a worse impact on physical functionality, still with gaps as to the best therapy for this patient. Final Considerations: Patients with concomitant Parkinson's disease and depression have a worse quality of life and motor symptoms.
Article Details
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
References
2. ANZALDI K e SHIFREN K. Optimism, Pessimism, Coping, and Depression: A Study on Individuals with Parkinson's Disease. The International Journal of Aging and Human Development, 2018; 88(3), 231-249.
3. CHEN J, et al. Non-pharmacological treatment for Parkinson disease patients with depression: a meta-analysis of repetitive transcranial magnetic stimulation and cognitive-behavioral treatment. International Journal of Neuroscience, 2021;131 (4):411-424.
4. CONG S, et al. Prevalence and Clinical aspects of Depression in Parkinson's Disease: A systematic review and meta-analysis of 129 studies. Neuroscience and Biobehavioral Reviews, 2022; 141: 1-7.
5. CRIPPA JAS, et al. Is cannabidiol the ideal drug to treat non-motor Parkinson’s disease symptoms?. European archives of psychiatry and clinical neuroscience, 2019; 269:121-133.
6. HONG CT et al. Psychotherapy for the Treatment of Anxiety and Depression in Patients with Parkinson Disease: A Meta-Analysis of Randomized Controlled Trials. Journal of the American Medical Directors Association, 2021; 22(11): 2289-2295.e2.
7. DEMARCO EC, et al.Exploring treatment for depression in Parkinson’s patients: a cross-sectional analysis. International journal of environmental research and public health, 2021;18 (16): 8596.
8. GALTS CPC, et al. Depression in neurodegenerative diseases: Common mechanisms and current treatment options. Neurosci Biobehav Rev. 2019; 102: 56-84.
9. HAI-JIAO W, et al. The efficacy of repetitive transcranial magnetic stimulation for Parkinson disease patients with depression. International Journal of Neuroscience, 2020; 130(1): 19-27.
10. HAN JW, et al. Psychiatric manifestation in patients with Parkinson's disease. Journal of Korean medical science,2018; 33(47): 1-17.
11. JENNER P, et al. Can adenosine A2A receptor antagonists be used to treat cognitive impairment, depression or excessive sleepiness in Parkinson’s disease? Parkinsonism & Related Disorders, 2020; 80(1): S28-S36.
12. KWOK JYY, et al. Efeitos do mindfulness yoga versus exercícios de alongamento e treinamento de resistência na ansiedade e depressão para pessoas com doença de Parkinson: um ensaio clínico randomizado. JAMA neurology ,2019; 76(7): 755-763.
13. LEE Y, et al. The presence of depression in de novo Parkinson's disease reflects poor motor compensation. PLoS One. 2018; 13(9): e0203303.
14. PATTERSON L, et al. Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders. Brain Pathology, 2019; 29(4): 544-557.
15. PONTONE GM e MILLS KA. Optimal Treatment of Depression and Anxiety in Parkinson's Disease. Am J Geriatr Psychiatry. 2021; 29(6): 530-540.
16. PRANGE S, et al. Depression in Patients with Parkinson’s Disease: Current Understanding of its Neurobiology and Implications for Treatment, 2022; 39(6), 417-439.
17. RYAN M, et al.Drug treatment strategies for depression in Parkinson disease. Expert opinion on pharmacotherapy, 2019; 20(11), 1351-1363.
18. SANTOS‐GARCÍA D, et al. Mood in Parkinson's disease: from early‐to late‐stage disease. International journal of geriatric psychiatry, 2021; 36(5): 627-646.
19. SHEN Q, et al. Impaired white matter microstructure associated with severe depressive symptoms in patients with PD. Brain Imaging and Behavior, 2022; 16: 169–175.
20. SU W, et al. Correlation between depression and quality of life in patients with Parkinson’s disease. Elsevier BV, Clinical Neurology And Neurosurgery, 2021; 202: e106523.
21. TAKAHASHI M, et al. Antidepressants for Depression, Apathy, and Gait Instability in Parkinson’s Disease: A Multicenter Randomized Study. Intern Med Advance Publication, 2018; 58(3): 361-368.
22. WEINTRAUB D e MAMIKONYAN E. The neuropsychiatry of Parkinson disease: a perfect storm. The American Journal of Geriatric Psychiatry, 2019; 27(9): 998-1018.