Prevalência, aspectos clínicos e tratamento da depressão na doença de parkinson

##plugins.themes.bootstrap3.article.main##

Ana Luiza Martins Porfirio
Nathana Santos Tomaz
Jéssica Hipólito Castilhas
Luana Borges Miranda
Sabrinna Letícia Ferreira Neto
Eduarda Vargas Rigo Herzog
Paulo Victor Gonçalves Secco
Aline Felipe da Costa Moreno
Beatriz Paganini da Cruz
Myrna Maria Costa de Melo Silveira

Resumo

Objetivo: Avaliar a prevalência da depressão em pacientes com doença de Parkinson, identificar os aspectos clínicos da depressão nessa população e analisar as opções de tratamentos disponíveis. Métodos: Por meio da plataforma de dados Pubmed, foi realizada uma revisão integrativa da literatura, com o intento de localizar fontes relevantes para tal. Foram utilizados os termos de pesquisa: Depression; Depressive Disorder; e Parkinson Disease, associados com operadores booleanos na seguinte estratégia de pesquisa: ((Depression) OR ("Depressive Disorder"[MeSH])) AND ("Parkinson Disease"[MeSH]), resultando em 1241 artigos iniciais. Dentro destes, apenas 22 artigos tornam-se fontes oficiais, conforme critérios de inclusão e exclusão. Resultados: Os estudos mostraram forte relação entre a Doença de Parkinson e a Depressão mesmo que subdiagnosticada e, consequentemente pior impacto na funcionalidade física, ainda com lacunas quanto à melhor terapêutica para estes pacientes. Considerações finais: Pacientes com Doença de Parkinson e Depressão concomitantes, têm piora na qualidade de vida e nos sintomas motores.

##plugins.themes.bootstrap3.article.details##

Como Citar
PorfirioA. L. M., TomazN. S., CastilhasJ. H., MirandaL. B., Ferreira NetoS. L., HerzogE. V. R., SeccoP. V. G., MorenoA. F. da C., CruzB. P. da, & SilveiraM. M. C. de M. (2023). Prevalência, aspectos clínicos e tratamento da depressão na doença de parkinson. Revista Eletrônica Acervo Saúde, 23(12), e15094. https://doi.org/10.25248/reas.e15094.2023
Seção
Revisão Bibliográfica

Referências

1. ANGELOPOULOU E, et al. Genetic Insights into the Molecular Pathophysiology of Depression in Parkinson’s Disease. Medicina, 2023; 59(6), 1138.

2. ANZALDI K e SHIFREN K. Optimism, Pessimism, Coping, and Depression: A Study on Individuals with Parkinson's Disease. The International Journal of Aging and Human Development, 2018; 88(3), 231-249.

3. CHEN J, et al. Non-pharmacological treatment for Parkinson disease patients with depression: a meta-analysis of repetitive transcranial magnetic stimulation and cognitive-behavioral treatment. International Journal of Neuroscience, 2021;131 (4):411-424.

4. CONG S, et al. Prevalence and Clinical aspects of Depression in Parkinson's Disease: A systematic review and meta-analysis of 129 studies. Neuroscience and Biobehavioral Reviews, 2022; 141: 1-7.

5. CRIPPA JAS, et al. Is cannabidiol the ideal drug to treat non-motor Parkinson’s disease symptoms?. European archives of psychiatry and clinical neuroscience, 2019; 269:121-133.

6. HONG CT et al. Psychotherapy for the Treatment of Anxiety and Depression in Patients with Parkinson Disease: A Meta-Analysis of Randomized Controlled Trials. Journal of the American Medical Directors Association, 2021; 22(11): 2289-2295.e2.

7. DEMARCO EC, et al.Exploring treatment for depression in Parkinson’s patients: a cross-sectional analysis. International journal of environmental research and public health, 2021;18 (16): 8596.

8. GALTS CPC, et al. Depression in neurodegenerative diseases: Common mechanisms and current treatment options. Neurosci Biobehav Rev. 2019; 102: 56-84.

9. HAI-JIAO W, et al. The efficacy of repetitive transcranial magnetic stimulation for Parkinson disease patients with depression. International Journal of Neuroscience, 2020; 130(1): 19-27.

10. HAN JW, et al. Psychiatric manifestation in patients with Parkinson's disease. Journal of Korean medical science,2018; 33(47): 1-17.

11. JENNER P, et al. Can adenosine A2A receptor antagonists be used to treat cognitive impairment, depression or excessive sleepiness in Parkinson’s disease? Parkinsonism & Related Disorders, 2020; 80(1): S28-S36.

12. KWOK JYY, et al. Efeitos do mindfulness yoga versus exercícios de alongamento e treinamento de resistência na ansiedade e depressão para pessoas com doença de Parkinson: um ensaio clínico randomizado. JAMA neurology ,2019; 76(7): 755-763.

13. LEE Y, et al. The presence of depression in de novo Parkinson's disease reflects poor motor compensation. PLoS One. 2018; 13(9): e0203303.

14. PATTERSON L, et al. Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders. Brain Pathology, 2019; 29(4): 544-557.

15. PONTONE GM e MILLS KA. Optimal Treatment of Depression and Anxiety in Parkinson's Disease. Am J Geriatr Psychiatry. 2021; 29(6): 530-540.

16. PRANGE S, et al. Depression in Patients with Parkinson’s Disease: Current Understanding of its Neurobiology and Implications for Treatment, 2022; 39(6), 417-439.

17. RYAN M, et al.Drug treatment strategies for depression in Parkinson disease. Expert opinion on pharmacotherapy, 2019; 20(11), 1351-1363.

18. SANTOS‐GARCÍA D, et al. Mood in Parkinson's disease: from early‐to late‐stage disease. International journal of geriatric psychiatry, 2021; 36(5): 627-646.

19. SHEN Q, et al. Impaired white matter microstructure associated with severe depressive symptoms in patients with PD. Brain Imaging and Behavior, 2022; 16: 169–175.

20. SU W, et al. Correlation between depression and quality of life in patients with Parkinson’s disease. Elsevier BV, Clinical Neurology And Neurosurgery, 2021; 202: e106523.

21. TAKAHASHI M, et al. Antidepressants for Depression, Apathy, and Gait Instability in Parkinson’s Disease: A Multicenter Randomized Study. Intern Med Advance Publication, 2018; 58(3): 361-368.

22. WEINTRAUB D e MAMIKONYAN E. The neuropsychiatry of Parkinson disease: a perfect storm. The American Journal of Geriatric Psychiatry, 2019; 27(9): 998-1018.