Associação entre doença periodontal e câncer de mama: revisão sistemática e metanálise
##plugins.themes.bootstrap3.article.sidebar##
Publicado
Feb 19, 2024
##plugins.themes.bootstrap3.article.main##
Resumo
Objetivo: Avaliar a possível associação entre a doença periodontal e o câncer de mama em mulheres. Métodos: Esta é uma revisão sistemática da literatura combinada com uma meta-análise. Cinco bases de dados foram pesquisadas, estudos relevantes publicados foram recuperados e selecionados. Os artigos foram avaliados e posteriormente sintetizados utilizando a metodologia PRISMA. Foram calculados Odds Ratios (OR) com intervalos de confiança (IC) de 95% para avaliar a associação entre DP e o risco de câncer de mama. Os artigos selecionados para metanálise foram separados em dois grupos, sendo: (a) estudos que não apresentaram exame clínico odontológico; (b) estudos que apresentaram exame clínico odontológico Resultados: Nos estudos que não incluíram exame clínico odontológico avaliou-se que mulheres sem doença periodontal têm um risco reduzido em 0,85 vezes de desenvolver câncer de mama, enquanto, estudos que incluíram avaliação odontológica clínica sugeriram que mulheres sem PD têm um risco reduzido em 0,50 vezes de desenvolver câncer de mama. Considerações finais: Estudos que avaliaram clinicamente a DP por meio de parâmetros odontológicos mostraram maior diminuição no número de pacientes com câncer de mama e doença periodontal
##plugins.themes.bootstrap3.article.details##
Como Citar
PirolaW. E., BarrosoE. M., GamaR. R., Santos NetoM. F. dos, TeodoroV. A., TozzoF. C. B. da S., & VieiraR. A. da C. (2024). Associação entre doença periodontal e câncer de mama: revisão sistemática e metanálise. Revista Eletrônica Acervo Saúde, 24(2), e15386. https://doi.org/10.25248/reas.e15386.2024
Seção
Revisão Bibliográfica
Copyright © | Todos os direitos reservados.
A revista detém os direitos autorais exclusivos de publicação deste artigo nos termos da lei 9610/98.
Reprodução parcial
É livre o uso de partes do texto, figuras e questionário do artigo, sendo obrigatória a citação dos autores e revista.
Reprodução total
É expressamente proibida, devendo ser autorizada pela revista.
Referências
AMABILE N, et al. Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease. J Intern Med, 2008; 6: 644-652.
2. ANWAR A, et al. The linkage of gum disease with oncogenesis of breast tumor in Pakistani women - A new prospective. Pakistan Journal of Medical and Health Sciences, 2013; 7(4): 945-947.
3. ARORA M, et al. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol, 2010; 171(2): 253-259.
4. BOYLE P and BOFFETTA P. Alcohol consumption and breast cancer risk. Breast Cancer Res, 2009; 11(3): S3.
5. BRAY F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018; 68(6): 394-424.
6. CHUNG SD, et al. A population-based study on the associations between chronic periodontitis and the risk of cancer. Int J Clin Oncol, 2016; 21(2): 219-223.
7. COLLABORATIVE GROUP ON HORMONAL FACTORS IN BREAST CANCER. Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet, 2002; 360(9328): 187-195.
8. CORBELLA S, et al. Is periodontitis a risk indicator for cancer? A meta-analysis. PLoS One, 2018; 13(4): e0195683.
9. DALL GV and BRITT KL, Estrogen Effects on the Mammary Gland in Early and Late Life and Breast Cancer Risk. Front Oncol, 2017; 7: 110.
10. DIZDAR O, et al. Increased cancer risk in patients with periodontitis. Mol Cancer, 2017; 33(12): 2195-2200.
11. DOMINY SS, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv, 2019; 5(1): eaau3333.
12. FREUDENHEIM JL, et al. Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women. Cancer Epidemiol Biomarkers Prev, 2016; 25(1): 43-50.
13. GAO S, et al. Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer. Infect Agent Cancer, 2016; 11: 3.
14. GONZALEZ-NAVARRO B, et al. Relationship between cardiovascular disease and dental pathology. Systematic review. Med Clin (Barc), 2017; 149(5): 211-216.
15. GUVEN DC, et al. Evaluation of cancer risk in patients with periodontal diseases. Journal of Clinical Oncology, 2018; 36(15): Conference Abstract.
16. HAN YW, et al. Periodontal disease, atherosclerosis, adverse pregnancy outcomes, and head-and-neck cancer. Adv Dent Res, 2014; 26(1): 47-55.
17. HEIKKILA P, et al. Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. Journal of Surgical Research, 2003; 111(1): 45-52.
18. HOWELL A, et al. Risk determination and prevention of breast cancer. Breast Cancer Res, 2014; 16(5): 446.
19. HUJOEL PP, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol, 2003; 13(5): 312-316.
20. INSTITUTO NACIONAL DO CÂNCER (INCA). Estimativa 2020 - Incidência de Câncer no Brasil. 2019. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa-2020-incidencia-de-cancer-no-brasil.pdf. Acessado em: 25 de outubro de 2023.
21. JIA M, et al. The association between periodontal disease and breast cancer in a prospective cohort study. Cancer Prev Res (Phila), 2020 13(12):1007-1016.
22. JIAN W, et al. Clinical and genetic characterization of hereditary breast cancer in a Chinese population. Hereditary Cancer in Clinical Practice, 2017; 15(19): 1-9.
23. KINANE DF, et al. Periodontal diseases. Nat Rev Dis Primers, 2017; 22(3): 17038.
24. LEIRA Y, et al. Association between periodontitis and ischemic stroke: a systematic review and meta-analysis. Eur J Epidemiol, 2017; 32(1): 43-53.
25. LUO J, et al. Association of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective cohort study. BMJ, 2011; 342: d1016.
26. MACCIO A and MADEDDU C. The role of interleukin-6 in the evolution of ovarian cancer: clinical and prognostic implications--a review. J Mol Med (Berl), 2013; 91(12): 1355-1368.
27. MAI X, et al. Periodontal disease severity and cancer risk in postmenopausal women: the Buffalo OsteoPerio Study. Cancer causes and Control, 2015; 27(2): 217-228.
28. MAISONNEUVE P, et al. Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis. Ann Oncol, 2017; 28(5): 985-995.
29. MICHAUD DS, et al. Periodontal Disease, Tooth Loss, and Cancer Risk. Epid Rev, 2017; 39(1): 49-58.
30. MICHAUD DS, et al. Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study. J Natl Cancer Inst, 2018; 110(8): 843-854.
31. MOHER D, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol, 2009; 62(10): 1006-1012.
32. NWIZU NN, et al. Periodontal disease and cancer: Epidemiologic studies and possible mechanisms. Periodontol 2000, 2020; 83(1): 213-233.
33. NWIZU NN, et al. Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women's Health Initiative Observational Cohort. Cancer Epidemiol Biomarkers Prev, 2017; 26(8): 1255-1265.
34. SAHINGUR SE and YEUDALL WA. Chemokine function in periodontal disease and oral cavity cancer. Front Immunol, 2015; 6: 214.
35. SEERIG LM, et al. Tooth loss in adults and income: Systematic review and meta-analysis. J Dent, 2015; 43(9): 1051-1059.
36. SFREDDO CS, et al. Periodontitis and breast cancer: A case-control study. Community Dent Oral Epidemiol, 2017; 45(6): 545-551.
37. SHAO J, et al. Periodontal disease and breast cancer: A meta-analysis of 1,73,162 participants. Frontiers in Oncology, 2018; 8:601.
38. SHI T, et al. Periodontal disease and susceptibility to breast cancer: A meta-analysis of observational studies. J Clin Periodontol, 2018; 45(9): 1025-1033.
39. SLIM K, et al. Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg, 2003; 73(9): 712-716.
40. SODER BPeriodontal disease may associate with breast cancer. Breast Cancer Res Treat, 2011; 127(2): 497-502.
41. TAZAWA PS, et al. Obesidade, um possível indicador de risco para a doença periodontal? [Obesity, a possible risk indicator for periodontal disease?]. Archives of Oral Research, 2011; 7(3): 311-320.
42. TIETZE K, et al. Differences in innate immune responses upon stimulation with gram-positive and gram-negative bacteria. J Periodontal Res, 2006; 41(5): 447-454.
43. VIEIRA RAdC, et al. Periodontal disease as a risk factor for breast cancer: A case-control study based on a comprehensive clinical periodontal evaluation Mastology 33, Supplement 1, 2023; BBCS Brazlian Breast Cancer Symposium 2023: in Press.
44. VIRTANEN E, et al. History of Dental Infections Associates with Cancer in Periodontally Healthy Subjects: A 24-Year Follow-Up Study from Sweden. Journal of Cancer, 2014; 5(2): 79-85.
45. WANG H, et al. Breast tissue, oral and urinary microbiomes in breast cancer. Oncotarget, 2017; 8(50): 88122-88138.
46. WANG J, et al. The risk of periodontitis for peripheral vascular disease: a systematic review. Rev Cardiovasc Med, 2019; 20(2): 81-89.
47. WANG J, et al. Relationship between periodontal disease and lung cancer: A systematic review and meta-analysis. J Periodontal Res, 2020; 55(5):581-593.
48. XIE WZ, et al. Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants. Front Physiol, 2018; 9: 979.
49. YAO QW, et al. Association of periodontal disease with oral cancer: a meta-analysis. Tumour Biol, 2014; 35(7): 7073-7077.
50. YE L, et al. Correlation between periodontal disease and oral cancer risk: A meta-analysis. J Cancer Res Ther, 2016; 12(Supplement): C237-C240.
51. YIN XH, et al. Association between Tooth Loss and Gastric Cancer: A Meta-Analysis of Observational Studies. PLoS One, 2016; 11(3): e0149653.
52. ZENG XT, et al. Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies. PLoS One, 2013; 8(10): e79017.
53. ZENG XT, et al. Periodontal Disease and Incident Lung Cancer Risk: A Meta-Analysis of Cohort Studies. J Periodontol, 2016; 87(10): 1158-1164.
2. ANWAR A, et al. The linkage of gum disease with oncogenesis of breast tumor in Pakistani women - A new prospective. Pakistan Journal of Medical and Health Sciences, 2013; 7(4): 945-947.
3. ARORA M, et al. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. Am J Epidemiol, 2010; 171(2): 253-259.
4. BOYLE P and BOFFETTA P. Alcohol consumption and breast cancer risk. Breast Cancer Res, 2009; 11(3): S3.
5. BRAY F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018; 68(6): 394-424.
6. CHUNG SD, et al. A population-based study on the associations between chronic periodontitis and the risk of cancer. Int J Clin Oncol, 2016; 21(2): 219-223.
7. COLLABORATIVE GROUP ON HORMONAL FACTORS IN BREAST CANCER. Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet, 2002; 360(9328): 187-195.
8. CORBELLA S, et al. Is periodontitis a risk indicator for cancer? A meta-analysis. PLoS One, 2018; 13(4): e0195683.
9. DALL GV and BRITT KL, Estrogen Effects on the Mammary Gland in Early and Late Life and Breast Cancer Risk. Front Oncol, 2017; 7: 110.
10. DIZDAR O, et al. Increased cancer risk in patients with periodontitis. Mol Cancer, 2017; 33(12): 2195-2200.
11. DOMINY SS, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv, 2019; 5(1): eaau3333.
12. FREUDENHEIM JL, et al. Periodontal Disease and Breast Cancer: Prospective Cohort Study of Postmenopausal Women. Cancer Epidemiol Biomarkers Prev, 2016; 25(1): 43-50.
13. GAO S, et al. Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer. Infect Agent Cancer, 2016; 11: 3.
14. GONZALEZ-NAVARRO B, et al. Relationship between cardiovascular disease and dental pathology. Systematic review. Med Clin (Barc), 2017; 149(5): 211-216.
15. GUVEN DC, et al. Evaluation of cancer risk in patients with periodontal diseases. Journal of Clinical Oncology, 2018; 36(15): Conference Abstract.
16. HAN YW, et al. Periodontal disease, atherosclerosis, adverse pregnancy outcomes, and head-and-neck cancer. Adv Dent Res, 2014; 26(1): 47-55.
17. HEIKKILA P, et al. Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. Journal of Surgical Research, 2003; 111(1): 45-52.
18. HOWELL A, et al. Risk determination and prevention of breast cancer. Breast Cancer Res, 2014; 16(5): 446.
19. HUJOEL PP, et al. An exploration of the periodontitis-cancer association. Ann Epidemiol, 2003; 13(5): 312-316.
20. INSTITUTO NACIONAL DO CÂNCER (INCA). Estimativa 2020 - Incidência de Câncer no Brasil. 2019. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa-2020-incidencia-de-cancer-no-brasil.pdf. Acessado em: 25 de outubro de 2023.
21. JIA M, et al. The association between periodontal disease and breast cancer in a prospective cohort study. Cancer Prev Res (Phila), 2020 13(12):1007-1016.
22. JIAN W, et al. Clinical and genetic characterization of hereditary breast cancer in a Chinese population. Hereditary Cancer in Clinical Practice, 2017; 15(19): 1-9.
23. KINANE DF, et al. Periodontal diseases. Nat Rev Dis Primers, 2017; 22(3): 17038.
24. LEIRA Y, et al. Association between periodontitis and ischemic stroke: a systematic review and meta-analysis. Eur J Epidemiol, 2017; 32(1): 43-53.
25. LUO J, et al. Association of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective cohort study. BMJ, 2011; 342: d1016.
26. MACCIO A and MADEDDU C. The role of interleukin-6 in the evolution of ovarian cancer: clinical and prognostic implications--a review. J Mol Med (Berl), 2013; 91(12): 1355-1368.
27. MAI X, et al. Periodontal disease severity and cancer risk in postmenopausal women: the Buffalo OsteoPerio Study. Cancer causes and Control, 2015; 27(2): 217-228.
28. MAISONNEUVE P, et al. Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis. Ann Oncol, 2017; 28(5): 985-995.
29. MICHAUD DS, et al. Periodontal Disease, Tooth Loss, and Cancer Risk. Epid Rev, 2017; 39(1): 49-58.
30. MICHAUD DS, et al. Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study. J Natl Cancer Inst, 2018; 110(8): 843-854.
31. MOHER D, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol, 2009; 62(10): 1006-1012.
32. NWIZU NN, et al. Periodontal disease and cancer: Epidemiologic studies and possible mechanisms. Periodontol 2000, 2020; 83(1): 213-233.
33. NWIZU NN, et al. Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women's Health Initiative Observational Cohort. Cancer Epidemiol Biomarkers Prev, 2017; 26(8): 1255-1265.
34. SAHINGUR SE and YEUDALL WA. Chemokine function in periodontal disease and oral cavity cancer. Front Immunol, 2015; 6: 214.
35. SEERIG LM, et al. Tooth loss in adults and income: Systematic review and meta-analysis. J Dent, 2015; 43(9): 1051-1059.
36. SFREDDO CS, et al. Periodontitis and breast cancer: A case-control study. Community Dent Oral Epidemiol, 2017; 45(6): 545-551.
37. SHAO J, et al. Periodontal disease and breast cancer: A meta-analysis of 1,73,162 participants. Frontiers in Oncology, 2018; 8:601.
38. SHI T, et al. Periodontal disease and susceptibility to breast cancer: A meta-analysis of observational studies. J Clin Periodontol, 2018; 45(9): 1025-1033.
39. SLIM K, et al. Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg, 2003; 73(9): 712-716.
40. SODER BPeriodontal disease may associate with breast cancer. Breast Cancer Res Treat, 2011; 127(2): 497-502.
41. TAZAWA PS, et al. Obesidade, um possível indicador de risco para a doença periodontal? [Obesity, a possible risk indicator for periodontal disease?]. Archives of Oral Research, 2011; 7(3): 311-320.
42. TIETZE K, et al. Differences in innate immune responses upon stimulation with gram-positive and gram-negative bacteria. J Periodontal Res, 2006; 41(5): 447-454.
43. VIEIRA RAdC, et al. Periodontal disease as a risk factor for breast cancer: A case-control study based on a comprehensive clinical periodontal evaluation Mastology 33, Supplement 1, 2023; BBCS Brazlian Breast Cancer Symposium 2023: in Press.
44. VIRTANEN E, et al. History of Dental Infections Associates with Cancer in Periodontally Healthy Subjects: A 24-Year Follow-Up Study from Sweden. Journal of Cancer, 2014; 5(2): 79-85.
45. WANG H, et al. Breast tissue, oral and urinary microbiomes in breast cancer. Oncotarget, 2017; 8(50): 88122-88138.
46. WANG J, et al. The risk of periodontitis for peripheral vascular disease: a systematic review. Rev Cardiovasc Med, 2019; 20(2): 81-89.
47. WANG J, et al. Relationship between periodontal disease and lung cancer: A systematic review and meta-analysis. J Periodontal Res, 2020; 55(5):581-593.
48. XIE WZ, et al. Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants. Front Physiol, 2018; 9: 979.
49. YAO QW, et al. Association of periodontal disease with oral cancer: a meta-analysis. Tumour Biol, 2014; 35(7): 7073-7077.
50. YE L, et al. Correlation between periodontal disease and oral cancer risk: A meta-analysis. J Cancer Res Ther, 2016; 12(Supplement): C237-C240.
51. YIN XH, et al. Association between Tooth Loss and Gastric Cancer: A Meta-Analysis of Observational Studies. PLoS One, 2016; 11(3): e0149653.
52. ZENG XT, et al. Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies. PLoS One, 2013; 8(10): e79017.
53. ZENG XT, et al. Periodontal Disease and Incident Lung Cancer Risk: A Meta-Analysis of Cohort Studies. J Periodontol, 2016; 87(10): 1158-1164.