Dinapenia em mulheres com diabetes mellitus tipo 2
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Jun 25, 2024
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Objetivo: Estimar a ocorrência e os fatores associados à dinapenia em mulheres adultas e idosas com diabetes mellitus tipo 2. Métodos: Estudo transversal realizado no ambulatório de endocrinologia de um hospital do Recife, entre julho/2022 e fevereiro/2023. Dinapenia foi definida quando a força de preensão palmar foi menor que 16 kg. Características sociodemográficas, clínicas, antropométricas, composição corporal e bioquímicas foram coletadas para determinar os fatores associados à dinapenia, por meio de análises bivariadas e regressão de Poisson robusta. Os dados foram analisados pelo software SPSS Statistics e o estudo foi aprovado pelo Comitê de ética em pesquisa. Resultados: Foram analisados os dados de 164 mulheres com idade média de 60,04 ± 9,02 anos. Identificou-se que 20,1% apresentavam dinapenia, e após análise de regressão, esta condição associou-se à baixa escolaridade (p=0,001), raça/cor branca (p=0,008), excesso de peso (p=0,015) e massa muscular reduzida (p<0,001). Conclusão: Observou-se neste estudo ocorrência elevada de dinapenia associada a diversos fatores de ordem sociodemográficas, antropométrica e de composição corporal. Estes resultados destacam a importância da avaliação desta condição com o objetivo de minimizar os efeitos adversos à saúde que a dinapenia pode causar nesta população.
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Como Citar
AraújoA. de A., SilvaN. K. D. A., BarbosaM. S. da S., Albuquerque SilvaP. F. de O., OliveiraJ. S., LealV. S., LemosM. da C. C. de, & ArrudaI. K. G. de. (2024). Dinapenia em mulheres com diabetes mellitus tipo 2. Revista Eletrônica Acervo Saúde, 24(6), e15891. https://doi.org/10.25248/reas.e15891.2024
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Referências
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26. PARK SW, et al. Decreased muscle strength and quality in older adults with type 2 diabetes: The health, aging, and body composition study. Diabetes, 2006; 55: 1813e1818.
27. RODRÍGUEZ-GARCÍA WD, et al. Prevalence of dynapenia and pre sarcopenia related to aging in adult community-dwelling Mexicans using two different cut-off points. Eur Geriatr Med., 2018; 9: 219-25.
28. RUIZ JCV, et al. Sarcopenia y dinapenia en pacientes con diabetes mellitus tipo 2 en un área rural de Castilla-La Mancha. REV CLÍN MED FAM., 2017; 10(2): 86-95.
29. SCOTT D, et al. Associations of sarcopenic obe-sity and dynapenic obesity with bone mineral density and incident fractures over 5-10 years in commu-nity-dwelling older adults. Calcif Tissue Int., 2016; 99(1): 30-42.
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32. SOCIEDADE BRASILEIRA DE DIABETES. Diretrizes da sociedade brasileira de diabetes 2019-2020. Disponível em: https://diretriz.diabetes.org.br. Acessado em: 10 de outubro de 2022.
33. TUTTLE LJ, et al. Lower physical activity is associated with higher intermuscular adipose tissue in people with type 2 diabetes and peripheral neuropathy. Phys Ther., 2011; 91: 923-30.
34. WHO. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995. Disponível em: https://iris.who.int/bitstream/handle/10665/37003/WHO_TRS_854.pdf?sequence=1&isAllowed=y. Acessado em: 11 de novembro de 2023.
35. WHO. Obesity: Preventing and managing the global epidemic. Report of a WHO Consultation on Obesity. Geneva, 3–5 June 1997 (1st ed.). Geneva: World Health Organization, 1998 WHO/NUT/NCD/98.1. Disponível em: https://iris.who.int/handle/10665/42330. Acessado em: 20 de junho de 2023.
36. YOON CH, et al. High glucose-induced jagged 1 in endothelial cells disturbs notch signaling for angiogenesis: A novel mechanism of diabetic vasculopathy. J Mol Cell Cardiol., 2014; 69: 52-66.
2. AMERICAN DIABETES ASSOCIATION. Standards of medical care in diabetes. Diabetes Care. 2023; 46 (Suppl 1): S216-S229. Disponível em: https://diabetesjournals.org/care/issue/46/Supplement_1. Acessado em: 10 de novembro de 2023.
3. ARAÚJO EM, et al. The use of the variable race/ color within public health: possibilities and limits. Interface Comunic Saúde Educ., 2009; 13: 383-94.
4. AROKIASAMY P e SELVAMANI Y. Age, socioeconomic patterns and regional variations in grip strength among older adults (50+) in India: Evidence from WHO's Study on Global Ageing and Adult Health (SAGE). Arch Gerontol Geriatr., 2018; 76: 100-105.
5. BARBOSA-SILVA TG, et al. Prevalence of sarcopenia among community-dwelling elderly of a medium-sized South American city: Results of the COMO VAI? Study. J Cachexia Sarcopenia Muscle, 2016; 7(2): 136–143.
6. BERTONI M, et al. Depressive symptoms and muscle weakness: a two-way relation? Exp Gerontol., 2018; 108: 87-91.
7. BORGES VS, et al. A nationwide study on prevalence and factors associated with dynapenia in older adults: ELSI-Brazil. Cad Saude Publica, 2020; 36(4): e00107319.
8. CASTANHEIRA M, et al. Associação de variáveis sóciodemográficas e compor-tamentais com a gordura abdominal em adultos: estudo de base populacional no Sul do Brasil. Cad Saúde Pública, 2003; 19 Suppl 1: S55-65.
9. CHEVAL B, et al. Association of early and adultlife socioeconomic circumstances with muscle strength in older age. Age Ageing, 2018; 47: 398-407.
10. COLLINS KH, et al. Obesity, metabolic syndrome, and musculoskeletal disease: Common inflammatory pathways suggest a central role for loss of muscle integrity. Front Physiol., 2018; 9.
11. CRUZ-JENTOFT AJ, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019; 48(1): 16-31.
12. DOBRETSOV M, et al. Early diabetic neuropathy: Triggers and mechanisms. World J Gastroenterol., 2007; 13: 175e191.
13. FREITAS MM, et al. Difference in sarcopenia prevalence and associated factors according to 2010 and 2018 European consensus (EWGSOP) in elderly patients with type 2 diabetes mellitus. Experimental Gerontology, 2020; 132: 110835.
14. FUCHS SC, et al. Reliability of race assessment based on the race of the ascendants: a cross-sectional study. BMC Public Health, 2002; 2: 1.
15. HICKS GE, et al. Absolute strength and loss of strength as predictors of mobility decline in older adults: the InCHIANTI study. Journals of Gerontology: Series A: Biomedical Sciences and Medical Sciences, 2012; 67(1): 66-73.
16. INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA. Pesquisa nacional de saúde: 2019: percepção do estado de saúde, estilos de vida, doenças crônicas e saúde bucal: Brasil e grandes regiões. Rio de Janeiro: IBGE; 2020. Disponível em: https://www.pns.icict.fiocruz.br/wp-content/uploads/2021/02/liv101764.pdf. Acessado em: 10 de outubro de 2023.
17. INTERNATIONAL DIABETES FEDERATION. IDF Diabetes Atlas: 10TH edition. 2021. Disponível em: www.diabetesatlas.org. Acessado em: 14 de Junho de 2022.
18. KRENTZ AJ, et al. Insulin resistance: a risk marker for disease and disability in the older person. Diabet Med., 2013; 30(5): 535-48.
19. LINO VTS, et al. Handgrip strength and factors associated in poor elderly assisted at a primary care unit in Rio de Janeiro, Brazil. PLoS One, 2016; 11: e0166373.
20. MANINI TM e CLARK BC. Dynapenia and Aging: An Update. J Gerontol A Biol Sci Med Sci., 2012; 67(1): 28-40.
21. MCLEAN RR, et al. Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2014; 69(5): 576-583.
22. MICHAUD M, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc., 2013; 14: 877-882.
23. MORETTO MC, et al. Association between race, obesity and diabetes in elderly community dwellers: data from the FIBRA study. Cad Saude Publica, 2016; 32(10): e00081315.
24. MORLEY JE, et al. Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology-update 2014. J Cachexia Sarcopenia Muscle, 2014; 5: 253-259.
25. ORGANIZAÇÃO PAN AMERICANA DA SAÚDE. XXXVI Reunión del Comitê Asesor de Ivestigaciones en Salud – Encuestra Multicêntrica – Salud Beinestar y Envejecimeiento (SABE) em América Latina e el Caribe. Informe preliminar. 2002. Disponível em: https://www1.paho.org/Spanish/HDP/HDR/CAIS-01-05.PDF. Acessado em: 20 de janeiro de 2021.
26. PARK SW, et al. Decreased muscle strength and quality in older adults with type 2 diabetes: The health, aging, and body composition study. Diabetes, 2006; 55: 1813e1818.
27. RODRÍGUEZ-GARCÍA WD, et al. Prevalence of dynapenia and pre sarcopenia related to aging in adult community-dwelling Mexicans using two different cut-off points. Eur Geriatr Med., 2018; 9: 219-25.
28. RUIZ JCV, et al. Sarcopenia y dinapenia en pacientes con diabetes mellitus tipo 2 en un área rural de Castilla-La Mancha. REV CLÍN MED FAM., 2017; 10(2): 86-95.
29. SCOTT D, et al. Associations of sarcopenic obe-sity and dynapenic obesity with bone mineral density and incident fractures over 5-10 years in commu-nity-dwelling older adults. Calcif Tissue Int., 2016; 99(1): 30-42.
30. SERGI G, et al. Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults. Clin. Nutr, 2015; 34(4): 667–673.
31. SILVA TAA, et al. Sarcopenia Associada ao Envelhecimento: Aspectos Etiológicos e Opções Terapêuticas. Rev Bras Reumatol., 2006; 46(6): 391-397.
32. SOCIEDADE BRASILEIRA DE DIABETES. Diretrizes da sociedade brasileira de diabetes 2019-2020. Disponível em: https://diretriz.diabetes.org.br. Acessado em: 10 de outubro de 2022.
33. TUTTLE LJ, et al. Lower physical activity is associated with higher intermuscular adipose tissue in people with type 2 diabetes and peripheral neuropathy. Phys Ther., 2011; 91: 923-30.
34. WHO. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995. Disponível em: https://iris.who.int/bitstream/handle/10665/37003/WHO_TRS_854.pdf?sequence=1&isAllowed=y. Acessado em: 11 de novembro de 2023.
35. WHO. Obesity: Preventing and managing the global epidemic. Report of a WHO Consultation on Obesity. Geneva, 3–5 June 1997 (1st ed.). Geneva: World Health Organization, 1998 WHO/NUT/NCD/98.1. Disponível em: https://iris.who.int/handle/10665/42330. Acessado em: 20 de junho de 2023.
36. YOON CH, et al. High glucose-induced jagged 1 in endothelial cells disturbs notch signaling for angiogenesis: A novel mechanism of diabetic vasculopathy. J Mol Cell Cardiol., 2014; 69: 52-66.