Efeito antimicrobiano do ácido ferúlico: uma revisão integrativa de bioensaios
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Apr 16, 2024
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Resumo
Objetivo: Identificar na literatura científica ensaios biológicos, in vitro, sobre a ação antimicrobiana do ácido ferúlico (FA). Métodos: O presente estudo trata-se de uma revisão integrativa da literatura, especialmente na base de dados PUBMED. Optou-se por realizar um estudo no período dos últimos 5 anos por conta das atualizações sobre a temática abordada. Resultados: Foram identificados um total de 682 nas base de dados, perfazendo uma amostra final de 09 trabalhos para a construção deste artigo. Atualmente as pesquisas no campo desenvolvimento de novos antimicrobianos com FA estão voltados a área de biomateriais. Sabe-se que o biomaterial que vem sendo mais utilizado nos estudos é a quitosana. Nesta revisão, 66,6% dos artigos selecionados contemplaram o uso de biofilmes e conjugados de FA e quitosana. As análises microbiológicas incluíram testes de concentração inibitória mínima e bactericida mínima. Foi possível verificar que o FA quando associado a quitosana apresenta melhor ação frente às cepas microbianas testadas. Considerações finais: O FA conjugado com a quitosana mostrou potenciais perspectivas de aplicação. No entanto, se faz necessário, mais pesquisas no âmbito multidisciplinar para o desenvolvimento de antimicrobianos e antibacterianos, que atualmente, são uma ameaça crescente à saúde global.
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Como Citar
NunesM. K. dos S., Chaves JúniorJ. V., SouzaF. S. de, AndradeP. N., CastroR. D. de, PêssoaH. de L. F., & SáR. de C. da S. e. (2024). Efeito antimicrobiano do ácido ferúlico: uma revisão integrativa de bioensaios. Revista Eletrônica Acervo Saúde, 24(4), e16186. https://doi.org/10.25248/reas.e16186.2024
Seção
Revisão Bibliográfica
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Referências
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11. EL-GOGARY RI, et al. Ferulic acid nanocapsules as a promising treatment modality for colorectal cancer: Preparation and in vitro/in vivo appraisal. Life Sci. 2022; 298: 120500.
12. EOM SH, et al. Synergistic Antibacterial Effect and Antibacterial Action Mode of Chitosan-Ferulic Acid Conjugate against Methicillin-Resistant Staphylococcus aureus. J Microbiol Biotechnol. 2016; 26 (4): 784-789.
13. HERNÁNDEZ-GARCÍA E, et al. Active Starch-Polyester Bilayer Films with Surface-Incorporated Ferulic Acid. Membranes (Basel). 2022; 12 (10): 976.
14. IBITOYE OB e AJIBOYE TO. Ferulic acid potentiates the antibacterial activity of quinolone-based antibiotics against Acinetobacter baumannii. Microb Pathog. 2019; 126: 393-398.
15. KANG J, et al. Ferulic acid inactivates Shigella flexneri through cell membrane destruction, biofilm retardation, and altered gene expression. Journal of Agricultural and Food Chemistry. 2020; 68 (27): 7121-7131.
16. KACZMAREK-SZCZEPAŃSKA B, et al. The Physicochemical and Antibacterial Properties of Chitosan-Based Materials Modified with Phenolic Acids Irradiated by UVC Light. Int J Mol Sci. 2021; 22 (12): 6472.
17. KOT B, et al. Antibacterial activity of commercial phytochemicals against Aeromonas species isolated from fish. Pathogens, 2019; 8 (3): 142.
18. LI D, et al. Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives. Life Sci. 2021; 284:119921.
19. LIN FH, et al. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 2005; 125 (4): 826-832.
20. MA X, et al. Ferulic acid isolated from propolis inhibits porcine parvovirus replication potentially through Bid-mediate apoptosis. Int Immunopharmacol. 2020; 83: 106379.
21. MASTOOR S, et al. Analysis of the Antimicrobial and Anti-Biofilm Activity of Natural Compounds and Their Analogues against Staphylococcus aureus Isolates. Molecules. 2022; 27 (20): 6874.
22. MAURYA DK e DEVASAGAYAM TPA. Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids. Food Chem Toxicol. 2010; 48 (12): 3369-3373.
23. RAJ ND e SINGH D. A critical appraisal on ferulic acid: Biological profile, biopharmaceutical challenges and nano formulations. Health Sciences Review, 2022; 5, 100063.
24. PATTNAIK S, et al. Ferulic acid encapsulated chitosan‐tripolyphosphate nanoparticles attenuate quorum sensing regulated virulence and biofilm formation in Pseudomonas aeruginosa PAO1. IET nanobiotechnology, 2018; 12 (8): 1056-1061.
25. PERNIN A, et al. Ferulic acid and eugenol have different abilities to maintain their inhibitory activity against Listeria monocytogenes in emulsified systems. Frontiers in Microbiology, 2019; 10: 137.
26. QIN Y e LI P. Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications. Int J Mol Sci. 2020; 21 (2): 499.
27. RAMPELOTTO CR, et al. Ferulic acid-loaded nanocapsules: Evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells. Toxicol In Vitro. 2022; 78: 105259.
28. ROY N, et al. Plant Phenolics Ferulic Acid and P-Coumaric Acid Inhibit Colorectal Cancer Cell Proliferation through EGFR Down-Regulation. Asian Pac J Cancer Prev. 2016; 17 (8): 4019-23.
29. RUKKUMANI R, et al. Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity. J Physiol Pharmacol. 2004; 55 (3): 551-61.
30. SHI C, et al. Antimicrobial Activity of Ferulic Acid Against Cronobacter sakazakii and Possible Mechanism of Action. Foodborne Pathog Dis. 2016; 13 (4): 196-204.
31. SHIRAI A, et al. Antifungal action of the combination of ferulic acid and ultraviolet-A irradiation against Saccharomyces cerevisiae. J Appl Microbiol. 2022; 132 (4): 2957-2967.
32. SIVAKUMAR S, et al. Ferulic acid loaded microspheres reinforced in 3D hybrid scaffold for antimicrobial wound dressing. Int J Biol Macromol. 2021; 1 (77): 463-473.
33. STOMPOR-GORĄCY M e MACHACZKA M. Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid. Int J Mol Sci. 2021; 22 (23): 12889.
34. TANG Z, et al. Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide. Molecules. 2023; 28 (4): 1720.
35. TEE-NGAM P, et al. Simple and rapid determination of ferulic acid levels in food and cosmetic samples using paper-based platforms. Sensors, 2013; 13 (10): 13039-13053.
36. XU JG, et al. Comparative study on inhibitory effects of ferulic acid and p-coumaric acid on Salmonella Enteritidis biofilm formation. World Journal of Microbiology and Biotechnology, 2022; 38 (8): 136.
37. YAKUB G, et al. Chitosan/ferulic acid-coated poly(ε-caprolactone) electrospun materials with antioxidant, antibacterial and antitumor properties. Int J Biol Macromol. 2018; 107 (Pt A): 689-702.
38. YAMAGUCHI T, et al. Time-Dependent Controlled Release of Ferulic Acid from Surface-Modified Hollow Nanoporous Silica Particles. Int J Mol Sci. 2023; 24 (13): 10560.
39. ZDUŃSKA K, et al. Antioxidant Properties of Ferulic Acid and Its Possible Application. Skin Pharmacol Physiol. 2018; 31 (6): 332-336.
40. ZHANG Y, et al. Structure-dependent inhibition of Stenotrophomonas maltophilia by polyphenol and its impact on cell membrane. Frontiers in Microbiology, 2019; 10: 2646.
2. ALMEIDA, MGC. Nanocarriers for skin delivery of cosmetic antioxidants, LISBOA. Dissertação (Mestrado Integrado em Ciências Farmacêutica) ̶ Escola de Ciências e Tecnologias da Saúde. Centro Universitário de Lisboa, Lisboa, 2018; 78 p.
3. ANAND S, et al. Electrospun biomimetic multifunctional nanofibers loaded with ferulic acid for enhanced antimicrobial and wound-healing activities in STZ-Induced diabetic rats. Pharmaceuticals, 2022; 15 (3): 302.
4. ANDRADE J, et al. Antimicrobial PLA-PVA multilayer films containing phenolic compounds. Food Chem. 2022; 375: 131861.
5. ARAGÓN-GUTIÉRREZ A, et al. Melt-Processed Bioactive EVOH Films Incorporated with Ferulic Acid. Polymers (Basel). 2020; 13(1): 68.
6. BORGES A, et al. Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria. Microb Drug Resist. 2013; 19 (4): 256-265.
7. BRIXNER B, et al. Antimicrobial activity of chitosan associated with essential oils in biomedical application: an integrative review. Research, Society and Development, 2022; 11 (14): e447111436563-e447111436563.
8. DASAGRANDHI C, et al. Antibacterial and Biofilm Modulating Potential of Ferulic Acid-Grafted Chitosan against Human Pathogenic Bacteria. Int J Mol Sci. 2018; 19 (8): 2157.
9. DE OLIVEIRA SILVA E e BATISTA R. Ferulic Acid and Naturally Occurring Compounds Bearing a Feruloyl Moiety: A Review on Their Structures, Occurrence, and Potential Health Benefits. Compr Rev Food Sci Food Saf. 2017; 16 (4): 580-616.
10. DE OLIVEIRA EF, et al. Screening of antimicrobial synergism between phenolic acids derivatives and UV-A light radiation. J Photochem Photobiol B. 2021; 214: 112081.
11. EL-GOGARY RI, et al. Ferulic acid nanocapsules as a promising treatment modality for colorectal cancer: Preparation and in vitro/in vivo appraisal. Life Sci. 2022; 298: 120500.
12. EOM SH, et al. Synergistic Antibacterial Effect and Antibacterial Action Mode of Chitosan-Ferulic Acid Conjugate against Methicillin-Resistant Staphylococcus aureus. J Microbiol Biotechnol. 2016; 26 (4): 784-789.
13. HERNÁNDEZ-GARCÍA E, et al. Active Starch-Polyester Bilayer Films with Surface-Incorporated Ferulic Acid. Membranes (Basel). 2022; 12 (10): 976.
14. IBITOYE OB e AJIBOYE TO. Ferulic acid potentiates the antibacterial activity of quinolone-based antibiotics against Acinetobacter baumannii. Microb Pathog. 2019; 126: 393-398.
15. KANG J, et al. Ferulic acid inactivates Shigella flexneri through cell membrane destruction, biofilm retardation, and altered gene expression. Journal of Agricultural and Food Chemistry. 2020; 68 (27): 7121-7131.
16. KACZMAREK-SZCZEPAŃSKA B, et al. The Physicochemical and Antibacterial Properties of Chitosan-Based Materials Modified with Phenolic Acids Irradiated by UVC Light. Int J Mol Sci. 2021; 22 (12): 6472.
17. KOT B, et al. Antibacterial activity of commercial phytochemicals against Aeromonas species isolated from fish. Pathogens, 2019; 8 (3): 142.
18. LI D, et al. Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives. Life Sci. 2021; 284:119921.
19. LIN FH, et al. Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 2005; 125 (4): 826-832.
20. MA X, et al. Ferulic acid isolated from propolis inhibits porcine parvovirus replication potentially through Bid-mediate apoptosis. Int Immunopharmacol. 2020; 83: 106379.
21. MASTOOR S, et al. Analysis of the Antimicrobial and Anti-Biofilm Activity of Natural Compounds and Their Analogues against Staphylococcus aureus Isolates. Molecules. 2022; 27 (20): 6874.
22. MAURYA DK e DEVASAGAYAM TPA. Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids. Food Chem Toxicol. 2010; 48 (12): 3369-3373.
23. RAJ ND e SINGH D. A critical appraisal on ferulic acid: Biological profile, biopharmaceutical challenges and nano formulations. Health Sciences Review, 2022; 5, 100063.
24. PATTNAIK S, et al. Ferulic acid encapsulated chitosan‐tripolyphosphate nanoparticles attenuate quorum sensing regulated virulence and biofilm formation in Pseudomonas aeruginosa PAO1. IET nanobiotechnology, 2018; 12 (8): 1056-1061.
25. PERNIN A, et al. Ferulic acid and eugenol have different abilities to maintain their inhibitory activity against Listeria monocytogenes in emulsified systems. Frontiers in Microbiology, 2019; 10: 137.
26. QIN Y e LI P. Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications. Int J Mol Sci. 2020; 21 (2): 499.
27. RAMPELOTTO CR, et al. Ferulic acid-loaded nanocapsules: Evaluation of mucosal interaction, safety and antioxidant activity in human mononucleated cells. Toxicol In Vitro. 2022; 78: 105259.
28. ROY N, et al. Plant Phenolics Ferulic Acid and P-Coumaric Acid Inhibit Colorectal Cancer Cell Proliferation through EGFR Down-Regulation. Asian Pac J Cancer Prev. 2016; 17 (8): 4019-23.
29. RUKKUMANI R, et al. Influence of ferulic acid on circulatory prooxidant-antioxidant status during alcohol and PUFA induced toxicity. J Physiol Pharmacol. 2004; 55 (3): 551-61.
30. SHI C, et al. Antimicrobial Activity of Ferulic Acid Against Cronobacter sakazakii and Possible Mechanism of Action. Foodborne Pathog Dis. 2016; 13 (4): 196-204.
31. SHIRAI A, et al. Antifungal action of the combination of ferulic acid and ultraviolet-A irradiation against Saccharomyces cerevisiae. J Appl Microbiol. 2022; 132 (4): 2957-2967.
32. SIVAKUMAR S, et al. Ferulic acid loaded microspheres reinforced in 3D hybrid scaffold for antimicrobial wound dressing. Int J Biol Macromol. 2021; 1 (77): 463-473.
33. STOMPOR-GORĄCY M e MACHACZKA M. Recent Advances in Biological Activity, New Formulations and Prodrugs of Ferulic Acid. Int J Mol Sci. 2021; 22 (23): 12889.
34. TANG Z, et al. Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide. Molecules. 2023; 28 (4): 1720.
35. TEE-NGAM P, et al. Simple and rapid determination of ferulic acid levels in food and cosmetic samples using paper-based platforms. Sensors, 2013; 13 (10): 13039-13053.
36. XU JG, et al. Comparative study on inhibitory effects of ferulic acid and p-coumaric acid on Salmonella Enteritidis biofilm formation. World Journal of Microbiology and Biotechnology, 2022; 38 (8): 136.
37. YAKUB G, et al. Chitosan/ferulic acid-coated poly(ε-caprolactone) electrospun materials with antioxidant, antibacterial and antitumor properties. Int J Biol Macromol. 2018; 107 (Pt A): 689-702.
38. YAMAGUCHI T, et al. Time-Dependent Controlled Release of Ferulic Acid from Surface-Modified Hollow Nanoporous Silica Particles. Int J Mol Sci. 2023; 24 (13): 10560.
39. ZDUŃSKA K, et al. Antioxidant Properties of Ferulic Acid and Its Possible Application. Skin Pharmacol Physiol. 2018; 31 (6): 332-336.
40. ZHANG Y, et al. Structure-dependent inhibition of Stenotrophomonas maltophilia by polyphenol and its impact on cell membrane. Frontiers in Microbiology, 2019; 10: 2646.