Avanços e perspectivas no tratamento da Síndrome de Tourette
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Oct 13, 2024
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Resumo
Objetivo: Compreender os principais avanços no tratamento da Síndrome de Tourette (ST), englobando as terapias farmacológicas e não farmacológica, nos últimos 5 anos. Métodos: Trata-se de uma revisão integrativa, realizada a partir de buscas nas bases de dados Publisher Medline (PubMed), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SCIELO) e Medical Literature Analysis and Retrievel System Online (MEDLINE), entre os anos de 2018 e 2023, utilizando descritores “Síndrome de Tourette” e “Tratamento” e suas traduções no inglês, com o uso do operador booleano AND. Resultados: 31 artigos foram selecionados para representar a amostra final e compor a revisão, por se adequarem aos critérios de inclusão e exclusão, nos quais a farmacoterapia, a estimulação cerebral profunda e a terapia comportamental se mostraram protagonistas no tratamento da síndrome. Considerações finais: Constatou-se que os fármacos valproato de sódio, tiaprida e priavanserina e a estimulação cerebral profunda podem ser usados para diminuir os sintomas motores dos pacientes, e que a terapia comportamental é uma ferramenta eficaz e necessária para a diminuição da gravidade e o controle dos tiques.
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Como Citar
BezerraF. Y., FreitasA. P. de, SousaV. K. T. de, AlmeidaV. E. G. de, & SoaresD. A. (2024). Avanços e perspectivas no tratamento da Síndrome de Tourette. Revista Eletrônica Acervo Saúde, 24(10), e16592. https://doi.org/10.25248/reas.e16592.2024
Seção
Revisão Bibliográfica
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Referências
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3. BADENOCH J e CAVANNA AE. Pharmacotherapy for tics in adult patients with Tourette syndrome and other tic disorders. Neurological Sciences, 2020; 41: 1923-1926.
4. BALDERMANN JC, et al. Thalamic deep brain stimulation for Tourette Syndrome: A naturalistic trial with brief randomized, double-blinded sham-controlled periods. Brain Stimulation, 2021; 14: 1059-1067.
5. BEHLER N, et al. Cathodal tDCS Over Motor Cortex Does Not Improve Tourette Syndrome: Lessons Learned from a Case Series. Front Behav Neurosci, 2018; 12: 194.
6. BILLNITZER A, et al. Pilot Study to Evaluate Pimavanserin for the Treatment of Motor and Behavioral Symptoms of Tourette Syndrome. Movement Disorders Clinical Practice, 2021; 8: 694-700.
7. BOTELHO LLR, et al. O método da revisão integrativa nos estudos organizacionais. Gestão e Sociedade, 2011; 5(11): 121-136.
8. CHEN J, et al. A Chinese herbal formulation, Xiao-Er-An-Shen decoction, attenuates tourettesyndrome, possibly by reversing abnormal changes in neurotransmitter levels and enhancing antioxidant status in mouse brain. Frontiers in pharmacology, 2019; 10: 812.
9. DONG C, et al. Utilizing network pharmacology to explore the underlying mechanism of Qiangzhidecoction in treating Tourette’s syndrome. Annals of Palliative Medicine, 2020; 9: 6.
10. DYKE K, et al. Effects of single-session cathodal transcranial direct current stimulation on tic symptoms in Tourette’s syndrome. Experimental brain research, 2019; 237: 2853-2863.
11. ESSOE JKY, et al. Homework adherence predicts therapeutic improvement from behavior therapy in Tourette's disorder. Behaviour Research and Therapy, 2021; 140: 103- 844.
12. FARHAT L, et al. Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis. Lancet Child Adolesc Health, 2023; 7: 112-126.
13. FEKETE S, et al. Correction to: Estimation of a preliminary therapeutic reference range for children and adolescents with tic disorders treated with tiapride. European journal of clinical pharmacology, 2021; 77: 8.
14. GARCIA-ACERO M, ESPINOSA E. Familial Tourette Syndrome: Case Re- port And Review Of Literature. Rev Ecuat Neurol, 2018; 27(2): 87-91.
15. GILBERT DL, et al. Ecopipam for Tourette Syndrome: A Randomized Trial. American Academy of Pediatrics, 2023; 151(2): 2022059574.
16. GORBERG V, et al. Different responses of repetitive behaviours in juvenile and young adult mice to Δ9-tetrahydrocannabinol and cannabidiol may affect decision making for Tourette syndrome. Br J Pharmacol, 2021; 178: 614-625.
17. HUANG C, et al. Effects of Yi-Gan-san on the psychiatric behavior of children and adolescents with Tourette's Syndrome: A randomized, double-blind, controlled preliminary study. Journal of Ethnopharmacology, 2022; 290: 115098.
18. JAFARI F, et al. Systematic Review and Meta-Analysis of Tourette Syndrome Prevalence; 1986 to 2022. Pediatr Neurol, 2022; 137: 6-16.
19. JO HJ, et al. Global network modulation during thalamic stimulation for Tourette syndrome. NeuroImage: Clinical, 2018; 18: 502-509.
20. JOHNSON KA, et al. Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021; 6: 961-972.
21. JOHNSON KA, et al. Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study. Journal of Neurology, Neurosurgery & Psychiatry, 2019; 90(10): 1078-1090.
22. KAHL CK, et al. Bilateral transcranial magnetic stimulation of the supplementary motor area in children with Tourette syndrome. Dev Med Child Neurol, 2021; 66(7): 808-815.
23. KWON OS, et al. Effects of orthopedic treatment using temporomandibular joint balancing appliance (TBA) at improving the symptoms of tic/Tourette syndrome: case report. Integr Med Res, 2018; 7(4): 381-386.
24. LI Y, et al. Protocol of a randomized controlled trial to investigate the efficacy and neural correlates of mindfulness-based habit reversal training in children with Tourette syndrome. Frontiers in Psychiatry, 2022; 13.
25. LI Y, et al. Stereotactic radiofrequency thermocoagulation application in the anterior limbs of patients’ internal capsules in treating intractable tic disorders. International Journal of Hyperthermia, 2020; 37(1): 332-337.
26. LOUREIRO NIV, et al. Tourette: por dentro da síndrome. Archives of Clinical Psychiatry, 2005; 32(4): 218-230.
27. MARTINO D, et al. The 5 pillars in Tourette syndrome deep brain stimulation patient selection: present and future. Neurology, 2021; 96(14): 664-676.
28. MCGUIRE JF, et al. Effect of Behavior Therapy for Tourette’s Disorder on Psychiatric Symptoms and Functioning in Adults. Psychological Medicine, 2020; 50: 2046-2056.
29. MCGUIRE JF, et al. Optimizing behavior therapy for youth with Tourette’s disorder. Neuropsychopharmacology, 2020; 45: 2114-2119.
30. MOLINA R, et al. Report of a patient undergoing chronic responsive deep brain stimulation for Tourette syndrome: proof of concept. Journal of Neurosurgery, 2018; 129: 308-314.
31. MULLER-VAHL KR, et al. Endocannabinoid modulation using monoacylglycerol lipase inhibition in Tourette syndrome: a phase 1 randomized, placebo-controlled study. Pharma-copsychiatry, 2022; 55(3): 148-156.
32. MULLER-VAHL KR, et al. European clinical guidelines for Tourette syndrome and other tic disorders: summary statement. Eur Child Adolesc Psychiatry, 2022; 31: 377-382.
33. PRINGSHEIM T, et al. Practice guideline recommendations summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders. Neurology, 2019; 92: 896-906.
34. RAMIREZ MD, et al. Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry. JAMA neurology, 2018; 75(3): 353-359.
35. RIZZO R, et al. A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths with Chronic Tic Disorder or Tourette Syndrome. Frontiers in Psychiatry, 2018; 9: 100.
36. RODRIGO L, et al. Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study. Nutrients, 2018; 10(5): 573.
37. TAO D, et al. Randomized controlled clinical trial comparing the efficacy and tolerability of aripiprazole and sodium valproate in the treatment of Tourette syndrome. Annals of General Psychiatry, 2019; 18(1): 1-9.
38. TEIXEIRA L, et al. Síndrome de La Tourette: Revisão de Literatura. Arquivos Internacionais de Otorrinolaringologia, 2011; 15: 492-500.
39. URRUTIA S e HERNANDEZ CH. Descripción de uma cohorte pediátrica com síndrome de Gilles de la Tourette. Andes Pediatrica, 2021; 92(6): 838.
40. YU W, et al. Jian-Pi-Zhi-Dong-Decoction regulates the expression of glutamate transporters to attenuate glutamate excitotoxicity and exerts anti-tics effects in Tourette syndrome model rats. Neuropsychiatr Dis Treat, 2018; 14: 3381–3392.
2. ANDRÉN P, et al. Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents with Tourette Syndrome: A Randomized Clinical Trial. JAMA Network Open, 2022; 5-8.
3. BADENOCH J e CAVANNA AE. Pharmacotherapy for tics in adult patients with Tourette syndrome and other tic disorders. Neurological Sciences, 2020; 41: 1923-1926.
4. BALDERMANN JC, et al. Thalamic deep brain stimulation for Tourette Syndrome: A naturalistic trial with brief randomized, double-blinded sham-controlled periods. Brain Stimulation, 2021; 14: 1059-1067.
5. BEHLER N, et al. Cathodal tDCS Over Motor Cortex Does Not Improve Tourette Syndrome: Lessons Learned from a Case Series. Front Behav Neurosci, 2018; 12: 194.
6. BILLNITZER A, et al. Pilot Study to Evaluate Pimavanserin for the Treatment of Motor and Behavioral Symptoms of Tourette Syndrome. Movement Disorders Clinical Practice, 2021; 8: 694-700.
7. BOTELHO LLR, et al. O método da revisão integrativa nos estudos organizacionais. Gestão e Sociedade, 2011; 5(11): 121-136.
8. CHEN J, et al. A Chinese herbal formulation, Xiao-Er-An-Shen decoction, attenuates tourettesyndrome, possibly by reversing abnormal changes in neurotransmitter levels and enhancing antioxidant status in mouse brain. Frontiers in pharmacology, 2019; 10: 812.
9. DONG C, et al. Utilizing network pharmacology to explore the underlying mechanism of Qiangzhidecoction in treating Tourette’s syndrome. Annals of Palliative Medicine, 2020; 9: 6.
10. DYKE K, et al. Effects of single-session cathodal transcranial direct current stimulation on tic symptoms in Tourette’s syndrome. Experimental brain research, 2019; 237: 2853-2863.
11. ESSOE JKY, et al. Homework adherence predicts therapeutic improvement from behavior therapy in Tourette's disorder. Behaviour Research and Therapy, 2021; 140: 103- 844.
12. FARHAT L, et al. Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis. Lancet Child Adolesc Health, 2023; 7: 112-126.
13. FEKETE S, et al. Correction to: Estimation of a preliminary therapeutic reference range for children and adolescents with tic disorders treated with tiapride. European journal of clinical pharmacology, 2021; 77: 8.
14. GARCIA-ACERO M, ESPINOSA E. Familial Tourette Syndrome: Case Re- port And Review Of Literature. Rev Ecuat Neurol, 2018; 27(2): 87-91.
15. GILBERT DL, et al. Ecopipam for Tourette Syndrome: A Randomized Trial. American Academy of Pediatrics, 2023; 151(2): 2022059574.
16. GORBERG V, et al. Different responses of repetitive behaviours in juvenile and young adult mice to Δ9-tetrahydrocannabinol and cannabidiol may affect decision making for Tourette syndrome. Br J Pharmacol, 2021; 178: 614-625.
17. HUANG C, et al. Effects of Yi-Gan-san on the psychiatric behavior of children and adolescents with Tourette's Syndrome: A randomized, double-blind, controlled preliminary study. Journal of Ethnopharmacology, 2022; 290: 115098.
18. JAFARI F, et al. Systematic Review and Meta-Analysis of Tourette Syndrome Prevalence; 1986 to 2022. Pediatr Neurol, 2022; 137: 6-16.
19. JO HJ, et al. Global network modulation during thalamic stimulation for Tourette syndrome. NeuroImage: Clinical, 2018; 18: 502-509.
20. JOHNSON KA, et al. Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021; 6: 961-972.
21. JOHNSON KA, et al. Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study. Journal of Neurology, Neurosurgery & Psychiatry, 2019; 90(10): 1078-1090.
22. KAHL CK, et al. Bilateral transcranial magnetic stimulation of the supplementary motor area in children with Tourette syndrome. Dev Med Child Neurol, 2021; 66(7): 808-815.
23. KWON OS, et al. Effects of orthopedic treatment using temporomandibular joint balancing appliance (TBA) at improving the symptoms of tic/Tourette syndrome: case report. Integr Med Res, 2018; 7(4): 381-386.
24. LI Y, et al. Protocol of a randomized controlled trial to investigate the efficacy and neural correlates of mindfulness-based habit reversal training in children with Tourette syndrome. Frontiers in Psychiatry, 2022; 13.
25. LI Y, et al. Stereotactic radiofrequency thermocoagulation application in the anterior limbs of patients’ internal capsules in treating intractable tic disorders. International Journal of Hyperthermia, 2020; 37(1): 332-337.
26. LOUREIRO NIV, et al. Tourette: por dentro da síndrome. Archives of Clinical Psychiatry, 2005; 32(4): 218-230.
27. MARTINO D, et al. The 5 pillars in Tourette syndrome deep brain stimulation patient selection: present and future. Neurology, 2021; 96(14): 664-676.
28. MCGUIRE JF, et al. Effect of Behavior Therapy for Tourette’s Disorder on Psychiatric Symptoms and Functioning in Adults. Psychological Medicine, 2020; 50: 2046-2056.
29. MCGUIRE JF, et al. Optimizing behavior therapy for youth with Tourette’s disorder. Neuropsychopharmacology, 2020; 45: 2114-2119.
30. MOLINA R, et al. Report of a patient undergoing chronic responsive deep brain stimulation for Tourette syndrome: proof of concept. Journal of Neurosurgery, 2018; 129: 308-314.
31. MULLER-VAHL KR, et al. Endocannabinoid modulation using monoacylglycerol lipase inhibition in Tourette syndrome: a phase 1 randomized, placebo-controlled study. Pharma-copsychiatry, 2022; 55(3): 148-156.
32. MULLER-VAHL KR, et al. European clinical guidelines for Tourette syndrome and other tic disorders: summary statement. Eur Child Adolesc Psychiatry, 2022; 31: 377-382.
33. PRINGSHEIM T, et al. Practice guideline recommendations summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders. Neurology, 2019; 92: 896-906.
34. RAMIREZ MD, et al. Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry. JAMA neurology, 2018; 75(3): 353-359.
35. RIZZO R, et al. A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths with Chronic Tic Disorder or Tourette Syndrome. Frontiers in Psychiatry, 2018; 9: 100.
36. RODRIGO L, et al. Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study. Nutrients, 2018; 10(5): 573.
37. TAO D, et al. Randomized controlled clinical trial comparing the efficacy and tolerability of aripiprazole and sodium valproate in the treatment of Tourette syndrome. Annals of General Psychiatry, 2019; 18(1): 1-9.
38. TEIXEIRA L, et al. Síndrome de La Tourette: Revisão de Literatura. Arquivos Internacionais de Otorrinolaringologia, 2011; 15: 492-500.
39. URRUTIA S e HERNANDEZ CH. Descripción de uma cohorte pediátrica com síndrome de Gilles de la Tourette. Andes Pediatrica, 2021; 92(6): 838.
40. YU W, et al. Jian-Pi-Zhi-Dong-Decoction regulates the expression of glutamate transporters to attenuate glutamate excitotoxicity and exerts anti-tics effects in Tourette syndrome model rats. Neuropsychiatr Dis Treat, 2018; 14: 3381–3392.