Prevalência e distribuição genotípica do papilomavírus humano (HPV) EM câncer de pênis no Brasil
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Resumo
Objetivo: Estimar a prevalência e a distribuição genotípica do Papilomavírus humano (HPV) no câncer de pênis no Brasil. Métodos: Trata-se de uma revisão sistemática e metanálise sobre os estudos que investigaram a prevalência e a distribuição genotípica do HPV no câncer de pênis em diferentes regiões do Brasil, usando métodos moleculares, no período de 2000 a 2021. A revisão foi cadastrada no International Prospective Register of Systematic Reviews (PROSPERO), conduzida de acordo com o Preferred Reporting of Systematic Reviews and Meta-Analysis Statement (PRISMA) e a qualidade dos estudos incluídos foi avaliada pelo Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Studies Reporting Prevalence Data. Resultados: 15 estudos foram incluídos, totalizando 1.250 casos. A prevalência combinada do HPV no câncer de pênis foi de 52,0% e a maior prevalência foi observada na região Nordeste (79%), seguida da região Norte (54%), Sudeste (44%) e Centro-Oeste (31%). O HPV16 foi o genótipo mais prevalente, seguido pelo HPV6, HPV11, HPV18, HPV51, HPV59, HPV74, HPV31, HPV35 e HPV68. Considerações finais: Nossos resultados confirmam a associação do HPV ao câncer de pênis e destacam a presença de genótipos virais não contemplados pela vacina profilática tetravalente distribuída pelo sistema público de saúde no Brasil.
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