Potencial terapêutico de fitoconstituintes da Dimorphandra gardneriana Tulasne e Anacardium occidentale L. na Doença de Alzheimer
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Resumo
Objetivo: Analisar o potencial terapêutico da Dimorphandra gardneriana Tulasne e Anacardium occidentale L. na Doença de Alzheimer (DA) e os possíveis mecanismos de ação envolvidos. Métodos: Trata-se de uma revisão integrativa da literatura, sendo realizada buscas nas bases de dados: Medline/ PubMed, Lilacs, Embase, Cochrane e Scopus. Ademais, foram incluídos artigos em inglês, estudos primários, in vivo, publicados no período de 2003 a 2023. Resultados: Foram selecionadas 19 publicações que investigaram os efeitos dos fitoconstituintes rutina, troxerrutina, quercetina e isoquercitrina presentes na D. gardneriana Tu. no tratamento da DA em ratos ou camundongos. Observou-se que essas substâncias promoveram redução do estresse oxidativo, da neuroinflamação, da síntese de β-amiloide (Aβ), da fosforilação da tau e da Acetilcolinesterase (AChE), promovendo melhora dos déficits cognitivos e danos cerebrais. Considerações finais: Esta revisão evidenciou que ainda não há tratamento clínico eficaz para esta condição e nenhuma maneira de impedir a morte das células cerebrais. Todavia, percebe-se que flavonoides da D. gardneriana Tu. tem mostrado resultados promissores para o tratamento dos sintomas da DA.
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