A relação entre a microbiota intestinal e o Transtorno do Espectro Autista
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Jan 21, 2025
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Resumo
Objetivo: Vários estudos apontam uma correlação da comunicação bidirecional entre microbiota intestinal e sistema nervoso central associado a transtornos cognitivos e neurodegenerativos e sintomas intestinais. Nesse sentido, o presente estudo visa analisar, por meio de revisão integrativa, os trabalhos que avaliam se há relação entre microbiota intestinal e o transtorno do espectro autista. Métodos: Para construir a metodologia, foram consultados dois bancos de dados de conteúdo médico-científico: PubMed e Lilacs. A pesquisa abrangeu artigos em inglês publicados entre 2014 e 2024, com foco em artigos primários. Um total de 149 artigos foram encontrados, dos quais 134 foram excluídos por não se adequarem ao tema proposto, resultando em 13 artigos para análise. Resultados: Durante o desenvolvimento do trabalho, observou-se que a interação do eixo intestino-cérebro exerce uma forte influência na microbiota intestinal de indivíduos no espectro do autismo, podendo levar ao desequilíbrio desse microbioma. Considerações finais: Foi constatada uma importante influência causal do eixo bidirecional cérebro-intestino-microbiota na etiologia e agravamento das manifestações clínicas do Transtorno do Espectro Autista devido à disbiose intestinal e a fatores gastrointestinais de origem idiopática.
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Como Citar
VaidelloM. O. X. de V., AlmeidaN. A. M., CecílioS. G., & PereiraL. M. de O. (2025). A relação entre a microbiota intestinal e o Transtorno do Espectro Autista. Revista Eletrônica Acervo Saúde, 25, e17038. https://doi.org/10.25248/reas.e17038.2025
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Referências
1. ALSHAMMARI MK, et al. Incidence of Clostridium perfringens and its toxin genes in the gut of children with autism spectrum disorder. Anaerobe, 2020; 102114.
2. BARAIBAR, R. Incidence and risk factors of acute otitis media in children. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 1997; 3(3): S13–S22.
3. BOLTE, E. R. Autism and clostridium tetani. Medical Hypotheses, 1998; 21(2): 133–144.
4. BONAZ B, et. al. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Frontiers in Neuroscience, 2018; 12(49).
5. CARISSIMI C, et al. Functional analysis of gut microbiota and immunoinflammation in children with autism spectrum disorders. Digestive and Liver Disease, 2019; 1(10): 1366–1374.
6. CHANG X, et al. Gut microbiome and serum amino acid metabolome alterations in autism spectrum disorder. Scientific Reports, 2024; 14(1): 4037.
7. CORTESE N, et al. The neuro-immune axis in cancer: Relevance of the peripheral nervous system to the disease. Immunology Letters, 2020.
8. FRANK MG, et al. Could Probiotics Be Used to Mitigate Neuroinflammation? ACS chemical neuroscience, 2018; 10(1): 13–15.
9. GANAL‐VONARBURG SC e DUERR CU. The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life. Immunology, 2019; 159(1): 39–51.
10. GIAU V, et al. Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease. Nutrients, 2018; 10(11): 1765.
11. GOMES DSA, et al. Alteração da microbiota intestinal e patologias associadas: importância do uso de prebióticos e probióticos no seu equilíbrio, Brasil. Temas em Saúde, 2019.
12. HUANG Y, et al. Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Reveals an Association of Nonspecific Interferon-c Secretion with Increased HIV-1 Infection Risk: A Cohort- Based Modeling Study. Plos One, 2014.
13. JENDRASZAK M, et al. Commercial microbiota test revealed differences in the composition of intestinal microorganisms between children with autism spectrum disorders and neurotypical peers. Scientific Reports, 2021; 11(1).
14. KIM CS, et al. Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community-dwelling elderly: A randomized, double-blind, placebo-controlled, multicenter trial. The Journals of Gerontology, 2020; 76(1).
15. KONG XJ, et al. Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial. Nutrients, 2021; 13(5): 1552.
16. LI W, et al. Structural changes of gut microbiota in Parkinson’s disease and its correlation with clinical features. Science China Life Sciences, 2017; 60(11): 1223–1233.
17. MARGOLIS KG, et al. The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology, 2021; 1486–1501.
18. MARTINEZ CLD. Microbiota intestinal, disbiose, nutrição e doença de Alzheimer: tem alguma relacao? Dissertação (pós-graduação em neurociências) - Universidade Federal de Minas Gerais, Belo Horizonte, Brasil, 2021.
19. MCKENNA CF, et al. Higher protein intake during resistance training does not potentiate strength, but modulates gut microbiota, in middle-aged adults: a randomized control trial. American Journal of Physiology-Endocrinology and Metabolism, 2021; 320(5): 900–913.
20. MEIJER K, et al Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health? Current Opinion in Clinical Nutrition and Metabolic Care, 2010; 13(6): 715–721.
21. MEIJER K, et. al. Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health? Current Opinion in Clinical Nutrition and Metabolic Care, 2010; 13(6): 715–721.
22. MOREIRA G, et. al. Obesidade, firmicutes e bacteroidetes: uma revisão da literatura. Dissertação - Centro Universitário de Brasília, 2018.
23. PAIXÃO LA e CASTRO FFS. Colonização da microbiota intestinal e sua influência na saúde do hospedeiro. Dissertação - Centro Universitário de Brasília, 2016.
24. PARK C, et al. Probiotics for the treatment of depressive symptoms: An anti-inflammatory mechanism? Brain, Behavior, and Immunity, 2018; 73: 115–124.
25. PENN AH, et al. Breast Milk Protects Against Gastrointestinal Symptoms in Infants at High Risk for Autism During Early Development. Journal of Pediatric Gastroenterology and Nutrition, 2016; 62(2): 317–327.
26. SANCTUARY MR, et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLOS ONE, 2019; 14(1): 210064.
27. SILVA JCL, et al. Microbiota Intestinal e Sistema Nervoso Central: explorando o eixo cérebro e intestino. Revista Neurociências, 2022; 30: 1–29.
28. SON JS, et al. Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection. PLOS ONE, 2015; 10(10): 137725.
29. SOUZA L. Clostridium perfringens: Uma revisão. Dissertação (pós-graduação) - Universidade federal de minas gerais (ufmg), instituto de ciências biológicas -icb departamento de microbiologia, Belo Horizonte-Brasil, 2017.
30. TOMOVA A, et al. Gastrointestinal microbiota in children with autism in Slovakia. Physiology & Behavior, 2015; 138: 179–187.
31. VAGAS ACCO, et al. Aspectos alimentares atuais e alteração da microbiota intestinal em indivíduos com obesidade/ Current dietary aspects and altered gut microbiota in obese individuals. Brazilian Journal of Health Review, 2021; 4(2): 5336–5352.
32. WAN Y, et al. Alterations in fecal virome and bacteriome virome interplay in children with autism spectrum disorder. Cell Reports. Medicine, 2024; 5(2): 101409.
33. WANG M, et al. Alteration of gut microbiota-associated epitopes in children with autism spectrum disorders. Brain, Behavior, and Immunity, 2019; 75: 192–199.
34. XIE X, et al. Alteration of the fecal microbiota in Chinese children with autism spectrum disorder. Autism Research, 2022.
35. YU Y, et al. Microbiota-gut-brain axis in autism spectrum disorder. Journal of Genetics and Genomics, 2021; 48(9): 755–762.
36. ZHANG L, et al. The role of probiotics in children with autism spectrum disorders: A study protocol for a randomised controlled trial. PloS One, 2022; 17(2): 263109.
37. ZWAIGENBAUM L, et al. Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research. PEDIATRICS, 2015; 136: S10–S40.
2. BARAIBAR, R. Incidence and risk factors of acute otitis media in children. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 1997; 3(3): S13–S22.
3. BOLTE, E. R. Autism and clostridium tetani. Medical Hypotheses, 1998; 21(2): 133–144.
4. BONAZ B, et. al. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Frontiers in Neuroscience, 2018; 12(49).
5. CARISSIMI C, et al. Functional analysis of gut microbiota and immunoinflammation in children with autism spectrum disorders. Digestive and Liver Disease, 2019; 1(10): 1366–1374.
6. CHANG X, et al. Gut microbiome and serum amino acid metabolome alterations in autism spectrum disorder. Scientific Reports, 2024; 14(1): 4037.
7. CORTESE N, et al. The neuro-immune axis in cancer: Relevance of the peripheral nervous system to the disease. Immunology Letters, 2020.
8. FRANK MG, et al. Could Probiotics Be Used to Mitigate Neuroinflammation? ACS chemical neuroscience, 2018; 10(1): 13–15.
9. GANAL‐VONARBURG SC e DUERR CU. The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life. Immunology, 2019; 159(1): 39–51.
10. GIAU V, et al. Gut Microbiota and Their Neuroinflammatory Implications in Alzheimer’s Disease. Nutrients, 2018; 10(11): 1765.
11. GOMES DSA, et al. Alteração da microbiota intestinal e patologias associadas: importância do uso de prebióticos e probióticos no seu equilíbrio, Brasil. Temas em Saúde, 2019.
12. HUANG Y, et al. Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Reveals an Association of Nonspecific Interferon-c Secretion with Increased HIV-1 Infection Risk: A Cohort- Based Modeling Study. Plos One, 2014.
13. JENDRASZAK M, et al. Commercial microbiota test revealed differences in the composition of intestinal microorganisms between children with autism spectrum disorders and neurotypical peers. Scientific Reports, 2021; 11(1).
14. KIM CS, et al. Probiotic supplementation improves cognitive function and mood with changes in gut microbiota in community-dwelling elderly: A randomized, double-blind, placebo-controlled, multicenter trial. The Journals of Gerontology, 2020; 76(1).
15. KONG XJ, et al. Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial. Nutrients, 2021; 13(5): 1552.
16. LI W, et al. Structural changes of gut microbiota in Parkinson’s disease and its correlation with clinical features. Science China Life Sciences, 2017; 60(11): 1223–1233.
17. MARGOLIS KG, et al. The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology, 2021; 1486–1501.
18. MARTINEZ CLD. Microbiota intestinal, disbiose, nutrição e doença de Alzheimer: tem alguma relacao? Dissertação (pós-graduação em neurociências) - Universidade Federal de Minas Gerais, Belo Horizonte, Brasil, 2021.
19. MCKENNA CF, et al. Higher protein intake during resistance training does not potentiate strength, but modulates gut microbiota, in middle-aged adults: a randomized control trial. American Journal of Physiology-Endocrinology and Metabolism, 2021; 320(5): 900–913.
20. MEIJER K, et al Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health? Current Opinion in Clinical Nutrition and Metabolic Care, 2010; 13(6): 715–721.
21. MEIJER K, et. al. Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health? Current Opinion in Clinical Nutrition and Metabolic Care, 2010; 13(6): 715–721.
22. MOREIRA G, et. al. Obesidade, firmicutes e bacteroidetes: uma revisão da literatura. Dissertação - Centro Universitário de Brasília, 2018.
23. PAIXÃO LA e CASTRO FFS. Colonização da microbiota intestinal e sua influência na saúde do hospedeiro. Dissertação - Centro Universitário de Brasília, 2016.
24. PARK C, et al. Probiotics for the treatment of depressive symptoms: An anti-inflammatory mechanism? Brain, Behavior, and Immunity, 2018; 73: 115–124.
25. PENN AH, et al. Breast Milk Protects Against Gastrointestinal Symptoms in Infants at High Risk for Autism During Early Development. Journal of Pediatric Gastroenterology and Nutrition, 2016; 62(2): 317–327.
26. SANCTUARY MR, et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLOS ONE, 2019; 14(1): 210064.
27. SILVA JCL, et al. Microbiota Intestinal e Sistema Nervoso Central: explorando o eixo cérebro e intestino. Revista Neurociências, 2022; 30: 1–29.
28. SON JS, et al. Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection. PLOS ONE, 2015; 10(10): 137725.
29. SOUZA L. Clostridium perfringens: Uma revisão. Dissertação (pós-graduação) - Universidade federal de minas gerais (ufmg), instituto de ciências biológicas -icb departamento de microbiologia, Belo Horizonte-Brasil, 2017.
30. TOMOVA A, et al. Gastrointestinal microbiota in children with autism in Slovakia. Physiology & Behavior, 2015; 138: 179–187.
31. VAGAS ACCO, et al. Aspectos alimentares atuais e alteração da microbiota intestinal em indivíduos com obesidade/ Current dietary aspects and altered gut microbiota in obese individuals. Brazilian Journal of Health Review, 2021; 4(2): 5336–5352.
32. WAN Y, et al. Alterations in fecal virome and bacteriome virome interplay in children with autism spectrum disorder. Cell Reports. Medicine, 2024; 5(2): 101409.
33. WANG M, et al. Alteration of gut microbiota-associated epitopes in children with autism spectrum disorders. Brain, Behavior, and Immunity, 2019; 75: 192–199.
34. XIE X, et al. Alteration of the fecal microbiota in Chinese children with autism spectrum disorder. Autism Research, 2022.
35. YU Y, et al. Microbiota-gut-brain axis in autism spectrum disorder. Journal of Genetics and Genomics, 2021; 48(9): 755–762.
36. ZHANG L, et al. The role of probiotics in children with autism spectrum disorders: A study protocol for a randomised controlled trial. PloS One, 2022; 17(2): 263109.
37. ZWAIGENBAUM L, et al. Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research. PEDIATRICS, 2015; 136: S10–S40.