Fitoterápicos como alternativa à irrigação e medicação intracanal convencional: uma revisão de literatura
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Publicado
Jan 31, 2025
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Resumo
Objetivo: Este estudo teve como objetivo realizar uma revisão integrativa da literatura sobre o tema: "Endodontia e Fitoterápicos", identificando quais fitoterápicos mostram resultados promissores para irrigação e medicação intracanal. Métodos: A revisão incluiu artigos das bases de dados PubMed, Scielo e da plataforma Biblioteca Virtual em Saúde (BVS), nos últimos dez anos e utilizando os descritores: “phytotherapy”, “phytotherapeutic drugs”, “plants, medicinal” e “endodontics” e seus respectivos termos em português, combinados pelo operador booleano “OR”. Foram incluídos estudos em português e inglês, tanto in vitro quanto clínicos, focados no uso de fitoterápicos na irrigação e medicação intracanal, enquanto revisões de literatura e estudos em animais foram excluídos. Resultados: Os fitoterápicos mais destacados foram: própolis, gengibre, extrato de alho, camomila, copaíba, romã, aroeira-da-praia, unha-de-gato e cravo-da-Índia. As principais atividades biológicas que favorecem o tratamento endodôntico identificadas foram: anti-inflamatória, antibacteriana, antisséptica, cicatrizante, analgésica e antifúngica. Conclusão: Conclui-se que os fitoterápicos são promissores para futuras investigações e podem ser candidatos eficazes para formulações de irrigação ou medicação intracanal em tratamentos endodônticos.
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Como Citar
SalesF. A. de S., PassosV. F., MarquesV. M., PintoS. A. H., BritoJ. X., & FerreiraR. G. L. de A. (2025). Fitoterápicos como alternativa à irrigação e medicação intracanal convencional: uma revisão de literatura. Revista Eletrônica Acervo Saúde, 25, e18492. https://doi.org/10.25248/reas.e18492.2025
Seção
Revisão Bibliográfica
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Referências
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2. BIRRING OJS, et al. Anti-microbialefficacyofAlliumsativumextractagainstEnterococcusfaecalisbiofilmand its penetrationintothe root dentin: An in vitro study. Indian Journalof Dental Research, 2015; 26(5): 477.
3. BOHNEBERGER G, et al. Fitoterápicos na odontologia, quando podemos utilizá-los? / Phytotherapy in dentistry, whencanwe use them? BrazilianJournalof Health Review, 2019; 2(4): 3504–3517.
4. CHUA EG, et al. Antifungaleffectivenessofvarious intracanal medicamentsagainstCandidaalbicans: anex-vivostudy. BMC Oral Health, 2014; 14(1).
5. COSTA COD, et al. Phytochemicalscreening, antioxidantandantibacterialactivitiesofextractspreparedfromdifferenttissuesofSchinusterebinthifoliusRaddithatoccurs in thecoastof Bahia, Brazil. Pharmacognosy Magazine, 2015; 11(43): 607–614.
6. DE OLIVEIRA VS, et al. Aroeira fruit (SchinusterebinthifoliusRaddi) as a natural antioxidant: Chemical constituents, bioactivecompoundsand in vitro and in vivo antioxidantcapacity. Food Chemistry, 2020; 315.
7. DE SÁ ASSIS MA, et al. AntimicrobialandantibiofilmeffectofBraziliangreenpropolisaqueousextractagainst dental anaerobicbacteria. Molecules, 2022; 27(23): 8128.
8. DE OLIVEIRA AB, et al. Potential use ofBraziliangreenpropolisextracts as new photosensitizers for antimicrobialphotodynamictherapyagainstcariogenicmicroorganisms. Pathogens, 2023; 12(2).
9. DE OLIVEIRA JR, et al. BiologicalactivitiesofRosmarinusofficinalis L. (rosemary) extract as analyzed in microorganismsandcells. Experimental Biologyand Medicine, 2017; 242(6): 625–634.
10. DHARIWAL NS, et al. A comparativeevaluationofantibacterialeffectivenessofsodiumhypochlorite, Curcuma longa, andCamelliasinensis as irrigatingsolutionsonisolatedanaerobicbacteriafrominfectedprimaryteeth. Journalof Indian Society ofPedodonticsandPreventiveDentistry, 2016; 34(2): 165–165.
11. EL-GUEDOUZ S, et al. MoroccanPropolis: A Natural Antioxidant, Antibacterial, andAntibiofilmagainstStaphylococcus aureus with No InductionofResistanceafterContinuousExposure. EvidBasedComplementAlternat Med. 2018; 2018: e9759240.
12. FAROOQ A, et al. ComparativeevaluationofSapindusMukorossiextractwith 17% EDTA onsmearlayerremoval in variouspartsofthetooth root. Journalof Applied Biomaterials&FunctionalMaterials, 2023; 21.
13. GIONGO M, et al. Analysisof pH and release ofcalciumofassociationbetweenmelaleucaalternifoliaoilandcalciumhydroxide. Revista de Odontologia da UNESP, 2017; 46(2): 104–108.
14. GOMES LAP, et al. Punica granatum L. (Pomegranate) extract: In vivo studyofantimicrobialactivityagainstPorphyromonasgingivalis in Galleria mellonella model. The Scientific World Journal, 2016; 2016: 1–5.
15. GUNESER MB, et al. Antibacterialeffectofchlorhexidine-cetrimidecombination, Salviaofficinalisplantextractandoctenidine in comparisonwithconventionalendodonticirrigants. Dental MaterialsJournal, 2016; 35(5): 736–741.
16. HERRERA DR, et al. AntimicrobialactivityandsubstantivityofUncaria tomentosa in infected root canal dentin. Brazilian Oral Research, 2016; 30(1).
17. ILDEFONSO J, et al. Plantas medicinais e fitoterápicos úteis na odontologia clínica: uma revisão. Revista da Faculdade de Odontologia da UFBA, 2020; 50(1): 47–56.
18. JAYAHARI NK, et al. The efficacyofpassionfruitjuice as anendodonticirrigantcomparedwithsodiumhypochloritesolution: an in vitro study. JournalofInvestigativeandClinicalDentistry, 2013; 5(2): 154–160.
19. KŘÍŽKOVSKÁ B, et al. Modulationofthebacterialvirulenceandresistancebywell-knownEuropean medicinal herbs. JournalofEthnopharmacology, 2023; 312.
20. LIBERATO SFS, et al. AntibiofilmactionofPersea americana glycolicextract over Acinetobacter baumannii andabsenceoftoxicity in Galleria mellonella. JournalofComplementary&Integrative Medicine, 2021; 19(4): 905–911.
21. MAEKAWA LE, et al. DifferentextractsofZingiberofficinaledecreaseEnterococcusfaecalisinfection in Galleria mellonella. Brazilian Dental Journal, 2015; 26(2): 105–109.
22. MECCATTI VM, et al. Antifungalactionof herbal plants’ glycolicextractsagainstCandidaspecies. Molecules, 2023; 28(6).
23. MEJÍA JBC. Antimicrobialeffectsofcalciumhydroxide, chlorhexidine, andpropolisonEnterococcusfaecalisandCandidaalbicans. JournalofInvestigativeandClinicalDentistry, 2014; 5(3): 194–200.
24. MENDOZA-JUACHE A, et al. The essentialoilofAlliumsativum as analternativeagentagainstCandidaisolatedfrom dental prostheses. Revista Iberoamericana de Micologia, 2017; 34(3): 158–164.
25. MOSTAQIM S, et al. Antibacterialactivitiesofclove (Syzygiumaromaticum) extractsagainstthree food borne pathogens: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Mymensingh Medical Journal, 2019; 28(4): 779–791.
26. PAROLIA A, et al. EffectofpropolisnanoparticlesagainstEnterococcusfaecalisbiofilm in the root canal. Molecules, 2021; 26(3): 715.
27. PAROLIA A, et al. Effectivenessofchitosan-propolisnanoparticleagainstEnterococcusfaecalisbiofilms in the root canal. BMC Oral Health, 2020; 20(1).
28. PRIYADARSHINI P, RAMAKRISHNAN M. ResorptionpotentialofEndoflaspowderwithcurcumin gel againstEndoflas for pulpectomy in primary mandibular molars: a one-year follow-up evidence-based case reports. Cureus. 2024; 16(6): e63231.
29. RAOOF M, et al. Antimicrobialefficacyofdifferent herbal extractsagainst root canal pathogens - An in vitro study. Indian Journalof Dental Research, 2023; 34(2): 204–208.
30. VALADAS LAR, et al. ClinicalandantimicrobialevaluationofCopaiferalangsdorffiiDesf. dental varnish in children: a clinicalstudy. EvidBasedComplementAlternat Med. 2021; 2021: e6647849.
31. SANTO E, et al. Fitoterapia como alternativa à medicação intracanal convencional. Revista Fitos, 2020; 14(3): 382–389.
32. SCHNEIDER LR, et al. Antibacterialactivityandphysicochemicalpropertiesof a sealercontainingcopaibaoil. Biofouling, 2023; 39(1): 110–120.
33. SEYYEDI SA, et al. The therapeuticeffectsofchamomillatincturemouthwashon oral aphthae: A RandomizedClinicalTrial. J ClinExp Dent, 2014; 6(5): 535–543.
34. SHAFIQ NE, et al. LeafExtractsof Moringa oleiferaCultivated in Baghdad: CharacterizationandAntimicrobialPotentialagainstEndodonticPathogens. The Scientific World Journal, 2024; 2024: e6658164.
35. SHAHA S, et al. Evaluationofantimicrobialeffectofazadirachtinplantextract (SoluneemTM) oncommonlyfound root canal pathogenicmicroorganisms (viz. Enterococcusfaecalis) in primaryteeth: A microbiologicalstudy. Journalof Indian Society ofPedodonticsandPreventiveDentistry, 2016; 34(3): 210.
36. SHARIFZADEH A, et al. AntifungaleffectofTrachyspermumammiagainstsusceptibleandfluconazole-resistantstrainsofCandidaalbicans. Journal de MycologieMedicale, 2015; 25(2): 143–150.
37. SILVA-JÚNIOR EJ, et al. Evidências do uso de fitoterápicos na odontologia: Uma revisão de literatura. Research, Society andDevelopment, 2021; 10(10): e113101018167.
38. SIQUEIRA JF, RÔÇAS IN. Present status and future directions: Microbiologyofendodonticinfections. InternationalEndodonticJournal, 2022; 55(S3): 512–530.
39. VALERA MC, et al. In vitro antimicrobialandanti-endotoxinactionofZingiberOfficinale as auxiliarychemicalandmedicamentcombinedtocalciumhydroxideandchlorhexidine. Acta OdontologicaScandinavica, 2015; 73(7): 556–561.
40. VERMA MK, et al. The antimicrobialeffectivenessof 25% propolisextract in root canal irrigationofprimaryteeth. Journalof Indian Society ofPedodonticsandPreventiveDentistry, 2014; 32(2): 120.
2. BIRRING OJS, et al. Anti-microbialefficacyofAlliumsativumextractagainstEnterococcusfaecalisbiofilmand its penetrationintothe root dentin: An in vitro study. Indian Journalof Dental Research, 2015; 26(5): 477.
3. BOHNEBERGER G, et al. Fitoterápicos na odontologia, quando podemos utilizá-los? / Phytotherapy in dentistry, whencanwe use them? BrazilianJournalof Health Review, 2019; 2(4): 3504–3517.
4. CHUA EG, et al. Antifungaleffectivenessofvarious intracanal medicamentsagainstCandidaalbicans: anex-vivostudy. BMC Oral Health, 2014; 14(1).
5. COSTA COD, et al. Phytochemicalscreening, antioxidantandantibacterialactivitiesofextractspreparedfromdifferenttissuesofSchinusterebinthifoliusRaddithatoccurs in thecoastof Bahia, Brazil. Pharmacognosy Magazine, 2015; 11(43): 607–614.
6. DE OLIVEIRA VS, et al. Aroeira fruit (SchinusterebinthifoliusRaddi) as a natural antioxidant: Chemical constituents, bioactivecompoundsand in vitro and in vivo antioxidantcapacity. Food Chemistry, 2020; 315.
7. DE SÁ ASSIS MA, et al. AntimicrobialandantibiofilmeffectofBraziliangreenpropolisaqueousextractagainst dental anaerobicbacteria. Molecules, 2022; 27(23): 8128.
8. DE OLIVEIRA AB, et al. Potential use ofBraziliangreenpropolisextracts as new photosensitizers for antimicrobialphotodynamictherapyagainstcariogenicmicroorganisms. Pathogens, 2023; 12(2).
9. DE OLIVEIRA JR, et al. BiologicalactivitiesofRosmarinusofficinalis L. (rosemary) extract as analyzed in microorganismsandcells. Experimental Biologyand Medicine, 2017; 242(6): 625–634.
10. DHARIWAL NS, et al. A comparativeevaluationofantibacterialeffectivenessofsodiumhypochlorite, Curcuma longa, andCamelliasinensis as irrigatingsolutionsonisolatedanaerobicbacteriafrominfectedprimaryteeth. Journalof Indian Society ofPedodonticsandPreventiveDentistry, 2016; 34(2): 165–165.
11. EL-GUEDOUZ S, et al. MoroccanPropolis: A Natural Antioxidant, Antibacterial, andAntibiofilmagainstStaphylococcus aureus with No InductionofResistanceafterContinuousExposure. EvidBasedComplementAlternat Med. 2018; 2018: e9759240.
12. FAROOQ A, et al. ComparativeevaluationofSapindusMukorossiextractwith 17% EDTA onsmearlayerremoval in variouspartsofthetooth root. Journalof Applied Biomaterials&FunctionalMaterials, 2023; 21.
13. GIONGO M, et al. Analysisof pH and release ofcalciumofassociationbetweenmelaleucaalternifoliaoilandcalciumhydroxide. Revista de Odontologia da UNESP, 2017; 46(2): 104–108.
14. GOMES LAP, et al. Punica granatum L. (Pomegranate) extract: In vivo studyofantimicrobialactivityagainstPorphyromonasgingivalis in Galleria mellonella model. The Scientific World Journal, 2016; 2016: 1–5.
15. GUNESER MB, et al. Antibacterialeffectofchlorhexidine-cetrimidecombination, Salviaofficinalisplantextractandoctenidine in comparisonwithconventionalendodonticirrigants. Dental MaterialsJournal, 2016; 35(5): 736–741.
16. HERRERA DR, et al. AntimicrobialactivityandsubstantivityofUncaria tomentosa in infected root canal dentin. Brazilian Oral Research, 2016; 30(1).
17. ILDEFONSO J, et al. Plantas medicinais e fitoterápicos úteis na odontologia clínica: uma revisão. Revista da Faculdade de Odontologia da UFBA, 2020; 50(1): 47–56.
18. JAYAHARI NK, et al. The efficacyofpassionfruitjuice as anendodonticirrigantcomparedwithsodiumhypochloritesolution: an in vitro study. JournalofInvestigativeandClinicalDentistry, 2013; 5(2): 154–160.
19. KŘÍŽKOVSKÁ B, et al. Modulationofthebacterialvirulenceandresistancebywell-knownEuropean medicinal herbs. JournalofEthnopharmacology, 2023; 312.
20. LIBERATO SFS, et al. AntibiofilmactionofPersea americana glycolicextract over Acinetobacter baumannii andabsenceoftoxicity in Galleria mellonella. JournalofComplementary&Integrative Medicine, 2021; 19(4): 905–911.
21. MAEKAWA LE, et al. DifferentextractsofZingiberofficinaledecreaseEnterococcusfaecalisinfection in Galleria mellonella. Brazilian Dental Journal, 2015; 26(2): 105–109.
22. MECCATTI VM, et al. Antifungalactionof herbal plants’ glycolicextractsagainstCandidaspecies. Molecules, 2023; 28(6).
23. MEJÍA JBC. Antimicrobialeffectsofcalciumhydroxide, chlorhexidine, andpropolisonEnterococcusfaecalisandCandidaalbicans. JournalofInvestigativeandClinicalDentistry, 2014; 5(3): 194–200.
24. MENDOZA-JUACHE A, et al. The essentialoilofAlliumsativum as analternativeagentagainstCandidaisolatedfrom dental prostheses. Revista Iberoamericana de Micologia, 2017; 34(3): 158–164.
25. MOSTAQIM S, et al. Antibacterialactivitiesofclove (Syzygiumaromaticum) extractsagainstthree food borne pathogens: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Mymensingh Medical Journal, 2019; 28(4): 779–791.
26. PAROLIA A, et al. EffectofpropolisnanoparticlesagainstEnterococcusfaecalisbiofilm in the root canal. Molecules, 2021; 26(3): 715.
27. PAROLIA A, et al. Effectivenessofchitosan-propolisnanoparticleagainstEnterococcusfaecalisbiofilms in the root canal. BMC Oral Health, 2020; 20(1).
28. PRIYADARSHINI P, RAMAKRISHNAN M. ResorptionpotentialofEndoflaspowderwithcurcumin gel againstEndoflas for pulpectomy in primary mandibular molars: a one-year follow-up evidence-based case reports. Cureus. 2024; 16(6): e63231.
29. RAOOF M, et al. Antimicrobialefficacyofdifferent herbal extractsagainst root canal pathogens - An in vitro study. Indian Journalof Dental Research, 2023; 34(2): 204–208.
30. VALADAS LAR, et al. ClinicalandantimicrobialevaluationofCopaiferalangsdorffiiDesf. dental varnish in children: a clinicalstudy. EvidBasedComplementAlternat Med. 2021; 2021: e6647849.
31. SANTO E, et al. Fitoterapia como alternativa à medicação intracanal convencional. Revista Fitos, 2020; 14(3): 382–389.
32. SCHNEIDER LR, et al. Antibacterialactivityandphysicochemicalpropertiesof a sealercontainingcopaibaoil. Biofouling, 2023; 39(1): 110–120.
33. SEYYEDI SA, et al. The therapeuticeffectsofchamomillatincturemouthwashon oral aphthae: A RandomizedClinicalTrial. J ClinExp Dent, 2014; 6(5): 535–543.
34. SHAFIQ NE, et al. LeafExtractsof Moringa oleiferaCultivated in Baghdad: CharacterizationandAntimicrobialPotentialagainstEndodonticPathogens. The Scientific World Journal, 2024; 2024: e6658164.
35. SHAHA S, et al. Evaluationofantimicrobialeffectofazadirachtinplantextract (SoluneemTM) oncommonlyfound root canal pathogenicmicroorganisms (viz. Enterococcusfaecalis) in primaryteeth: A microbiologicalstudy. Journalof Indian Society ofPedodonticsandPreventiveDentistry, 2016; 34(3): 210.
36. SHARIFZADEH A, et al. AntifungaleffectofTrachyspermumammiagainstsusceptibleandfluconazole-resistantstrainsofCandidaalbicans. Journal de MycologieMedicale, 2015; 25(2): 143–150.
37. SILVA-JÚNIOR EJ, et al. Evidências do uso de fitoterápicos na odontologia: Uma revisão de literatura. Research, Society andDevelopment, 2021; 10(10): e113101018167.
38. SIQUEIRA JF, RÔÇAS IN. Present status and future directions: Microbiologyofendodonticinfections. InternationalEndodonticJournal, 2022; 55(S3): 512–530.
39. VALERA MC, et al. In vitro antimicrobialandanti-endotoxinactionofZingiberOfficinale as auxiliarychemicalandmedicamentcombinedtocalciumhydroxideandchlorhexidine. Acta OdontologicaScandinavica, 2015; 73(7): 556–561.
40. VERMA MK, et al. The antimicrobialeffectivenessof 25% propolisextract in root canal irrigationofprimaryteeth. Journalof Indian Society ofPedodonticsandPreventiveDentistry, 2014; 32(2): 120.