Autismo, distúrbios do sono e o fenótipo insone: uma análise cienciométrica e integrativa
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Oct 8, 2024
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Resumo
Objetivo: Mapear o panorama do conhecimento sobre o autismo associado a distúrbios do sono e sintetizar o avanço na pesquisa sobre o fenótipo insone. Métodos: Trata-se de revisão cienciométrica e integrativa da literatura na base de dados web of science. Para a revisão integrativa, utilizou-se a seguinte questão norteadora: Quais os avanços científicos no fenótipo do transtorno do espectro autista (TEA) associado a insônia? Os textos selecionados eram em inglês ou português, publicados entre 2019 e 2024. Resultados: 69 artigos foram incluídos em análise cienciométrica, sendo 69,6% pesquisas originais. 62,3% focaram nos sinais e sintomas, diagnóstico e tratamento. 16 artigos atenderam aos critérios de inclusão e exclusão para revisão integrativa. Houveram avanços na investigação dos genes do ritmo circadiano e do metabolismo do ferro, hiperreatividade sensorial e hiperexcitação fisiológica. Encontrou-se uma correlação positiva com o estresse parental. Notou-se uma escassez de inquéritos epidemiológicos. Quanto ao tratamento, a terapia cognitivo-comportamental para insônia se mostra promissora. Por outro lado, a melatonina tem indicações limitadas e a suplementação de ferro não foi recomendada. Considerações finais: Apesar dos avanços recentes e crescente produção científica, os resultados indicam a necessidade de mais investigações, estudos epidemiológicos e abordagens terapêuticas para melhorar a qualidade do sono desses indivíduos.
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Como Citar
PereiraD. C., OliveiraR. A. de, CardosoR. M., & SilvaY. G. da. (2024). Autismo, distúrbios do sono e o fenótipo insone: uma análise cienciométrica e integrativa. Revista Eletrônica Acervo Saúde, 24(10), e18564. https://doi.org/10.25248/reas.e18564.2024
Seção
Revisão Bibliográfica
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Referências
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://www.gov.br/mcti/pt-br/acompanhe-o-mcti/indicadores/paginas/comparacoes-internacionais/recursos-aplicados/8-1-2-dispendios-nacionais-em-pesquisa-e-desenvolvimento-em-relacao-ao-produto-interno-bruto-pib-de-paises-selecionados. Acessado em 26 de maio de 2024.
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13. GEORÉN L, et al. Internet-delivered cognitive behavioral therapy for insomnia in youth with autism spectrum disorder: A pilot study. Internet interventions, 2020; 29: 100548.
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15. HOHN VD, et al. Insomnia severity in adults with autism spectrum disorder is associated with sensory hyper-reactivity and social skill impairment. Journal of autism and developmental disorders, 2019; 49(5): 2146–2155.
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24. MCCRAE CS, et al. Cognitive behavioral treatment of insomnia in school‐aged children with autism spectrum disorder: A pilot feasibility study. Autism research, 2020; 13(1): 167-176.
25. MCCRAE CS, et al. Telehealth cognitive behavioral therapy for insomnia in children with autism spectrum disorder: A pilot examining feasibility, satisfaction, and preliminary findings. Autism, 2021; 25(3): 667-680.
26. MELTZER LJ. Brief Report: Sleep in parents of children with autism spectrum disorders. Journal of pediatric psychology, 2008; 33(4): 380–386.
27. MENDES KDS, et al. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto - Enfermagem, 2008; 17(4): 758–764.
28. MENGYU L, et al. Recent Developments in Autism Genetic Research: A Scientometric Review from 2018 to 2022. Genes (Basel), 2022; 13(9): 1646.
29. NIARCHOU M, et al. Investigating the genetic pathways of insomnia in Autism Spectrum Disorder. Research in developmental disabilities, 2022; 128: 128-104299.
30. NOGUEIRA HA, et al. Melatonin for sleep disorders in people with autism: Systematic review and meta-analysis. Progress in neuro-psychopharmacology and biological psychiatry, 2023; 123: 110695.
31. ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE. Transtorno do espectro autista. Disponivel em: https ://www.paho.org/pt/topicos/transtorno-do-espectro-autista. Acesso em: 30 maio.2023.
32. PELLICANO E, et al. What should autism research focus upon? Community views and priorities from the United Kingdom. Autism, 2014; 18(7): 756-770.
33. REYNOLDS AM, et al. Randomized, placebo-controlled trial of ferrous sulfate to treat insomnia in children with autism spectrum disorders. Pediatric neurology, 2020; 104: 30–39.
34. RIEMANN, D. et al. The european insomnia guideline: An update on the diagnosis and treatment of insomnia 2023. Journal of sleep research, 2023; 32(6): 14035.
35. SINHA C, et al. Qualitative exploration toward the development of a parent-rated scale for insomnia in children with autism spectrum disorder. Journal of autism and developmental disorders, 2023; 54: 1792-1803.
36. SKONIECZNA-ŻYDECKA K, et al. The prevalence of insomnia and the link between iron metabolism genes polymorphisms, TF rs1049296 C>T, TF rs3811647 G>A, TFR rs7385804 A>C, HAMP rs10421768 A>G and sleep disorders in polish individuals with ASD. International journal of environmental research and public health, 2020; 17(2): 400.
37. SOCIEDADE BRASILEIRA DE PEDIATRIA. Transtorno do espectro do autismo. São Paulo: SBP, 2019. Disponível em: https ://www.sbp.com.br/fileadmin/user_upload/Ped._Desenvolvimento_-_21775b-MO_-_Transtorno_do_Espectro_do_Autismo.pdf. Acessado em: 30 de maio de 2023.
38. SOUDERS MC, et al. Sleep in Children with Autism Spectrum Disorder, 2018; 19(6): 34.
39. TAN-MACNEILL KM, et al. Barriers and facilitators to treating insomnia in children with autism spectrum disorder and other neurodevelopmental disorders: Parent and health care professional perspectives. Research in developmental disabilities, 2020; 107: 103792.
40. TAYLOR BJ, et al. Insomnia subtypes and clinical impairment in hospitalized children with autism spectrum disorder. Autism, 2020; 25(3): 656–666.
41. TESFAYE R, et al. Investigating the contributions of circadian pathway and insomnia risk genes to autism and sleep disturbances. Translational psychiatry, 2022; 12: 424.
42. VEATCH OJ, et al. Pleiotropic genetic effects influencing sleep and neurological disorders. the lancet. Neurology, 2017;16(2): 158-170.
43. WORLD HEALTH ORGANIZATION. Autism spectrum disorders. Disponível em: https ://www.who.int/news-room/fact-sheets/detail/autism-spectrum-disorders. Acesso em 30 maio. 2023.
44. XIONG M, et al. Efficacy of melatonin for insomnia in children with autism spectrum disorder: A meta-analysis. Neuropediatrics, 2023; 54(3): 167–173.
2. BAKER EK, et al. Assessing a hyperarousal hypothesis of insomnia in adults with autism spectrum disorder. autism research, 2019; 12(6): 897–910.
3. BANASCHEWSKI T, et al. Practice tools for screening and monitoring insomnia in children and adolescents with autism spectrum disorder. Journal of autism and developmental disorders, 2021; 52(8): 3758-3768.
4. BERLOCO B, et al. Insomnia in children with autism spectrum disorder: a cross-sectional study on clinical correlates and parental stress. Journal of autism and developmental disorders, 2022; 54: 46-55.
5. BRASIL. Lei nº 13.861, de 18 de julho de 2019. Altera a Lei nº 7.853, de 24 de outubro de 1989, para determinar a inclusão de informações sobre pessoas com transtorno do espectro autista nos censos demográfico. Disponível em: https
://pesquisa.in.gov.br/imprensa/jsp/visualiza/index.jsp?data=19/07/2019&jornal=515&pagina=1. Acessado em: 30 de maio de 2023.
6. BRASIL. Ministério da ciência, tecnologia e inovação. 8.1.2 - Dispêndios nacionais em pesquisa e desenvolvimento em relação ao produto interno bruto (PIB) de países selecionados. Disponível em: https
://www.gov.br/mcti/pt-br/acompanhe-o-mcti/indicadores/paginas/comparacoes-internacionais/recursos-aplicados/8-1-2-dispendios-nacionais-em-pesquisa-e-desenvolvimento-em-relacao-ao-produto-interno-bruto-pib-de-paises-selecionados. Acessado em 26 de maio de 2024.
7. BRASIL. Ministério da saúde. Secretaria de atenção à saúde. Diretrizes de atenção à reabilitação da pessoa com transtornos do espectro do autismo. Brasília: Ministério da saúde, 2014. Disponível em: https ://pesquisa.in.gov.br/imprensa/jsp/visualiza/index.jsp?data=19/07/2019&jornal=515&pagina=1. Acessado em: 30 de maio de 2023.
8. BUCKLEY AW, et al. Practice guideline: treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology, 2020; 94(9): 392-404.
9. CHEN H, et al. Sleep problems in children with autism spectrum disorder: a multicenter survey. BMC Psychiatry, 2021; 21(1): 406.
10. COHEN S, et al. The relationship between sleep and behavior in autism spectrum disorder (ASD): a review. Journal of neurodevelopmental disorders, 2014; 6(1): 44.
11. CORTESE S, et al. Sleep disorders in children and Adolescents with autism spectrum disorder: diagnosis, epidemiology, and management. CNS Drugs, 2020; 34(4): 415-423.
12. GEOFFRAY MM, et al. Are circadian rhythms new pathways to understand autism spectrum disorder? Journal of physiology-Paris, 2016; 110(4): 434–438.
13. GEORÉN L, et al. Internet-delivered cognitive behavioral therapy for insomnia in youth with autism spectrum disorder: A pilot study. Internet interventions, 2020; 29: 100548.
14. HERRMANN S. Counting sheep: sleep disorders in children with autism spectrum disorders. Journal of pediatric health care, 2016; 30(2): 143–154.
15. HOHN VD, et al. Insomnia severity in adults with autism spectrum disorder is associated with sensory hyper-reactivity and social skill impairment. Journal of autism and developmental disorders, 2019; 49(5): 2146–2155.
16. JANSEN PR, et al. Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. Nature Genetics, 2019; 51(3): 394–403.
17. KAYFENG L, et al. A bibliometric analysis of autism spectrum disorder signaling pathways research in the past decade. Frontiers in psychiatry, 2024; 15: 1304916.
18. KEOGH S, et al. Effectiveness of non-pharmacological interventions for insomnia in children with autism spectrum disorder: A systematic review and meta-analysis. PLOS ONE, 2019; 14(8): 0221428.
19. KIRKPATRICK B, et al. Qualitative study on parents’ perspectives of the familial impact of living with a child with autism spectrum disorder who experiences insomnia. Sleep medicine, 2019; 62: 59-68.
20. KUNDU GK, et al. Sleep disturbance in children with autism spectrum disorder: a cross sectional study. Mymensingh medical journal: MMJ, 2022; 31(3): 758–766.
21. LARA KDG, et al. Sleep disturbances in children with autism spectrum disorder and their individual and family affectation. A single-center observational study in Mexico.Ecuadorian Journal of Pediatrics 2022;23(3): 201-206.
22. MAENNER MJ, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years — autism and developmental disabilities monitoring network, 11 sites, United States, 2020. MMWR. Surveillance Summaries, 2023; 72(2): 1–14.
23. MAURER JJ, et al. Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics. Neurobiology of sleep and circadian rhythms, 2023; 14: 100095.
24. MCCRAE CS, et al. Cognitive behavioral treatment of insomnia in school‐aged children with autism spectrum disorder: A pilot feasibility study. Autism research, 2020; 13(1): 167-176.
25. MCCRAE CS, et al. Telehealth cognitive behavioral therapy for insomnia in children with autism spectrum disorder: A pilot examining feasibility, satisfaction, and preliminary findings. Autism, 2021; 25(3): 667-680.
26. MELTZER LJ. Brief Report: Sleep in parents of children with autism spectrum disorders. Journal of pediatric psychology, 2008; 33(4): 380–386.
27. MENDES KDS, et al. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto - Enfermagem, 2008; 17(4): 758–764.
28. MENGYU L, et al. Recent Developments in Autism Genetic Research: A Scientometric Review from 2018 to 2022. Genes (Basel), 2022; 13(9): 1646.
29. NIARCHOU M, et al. Investigating the genetic pathways of insomnia in Autism Spectrum Disorder. Research in developmental disabilities, 2022; 128: 128-104299.
30. NOGUEIRA HA, et al. Melatonin for sleep disorders in people with autism: Systematic review and meta-analysis. Progress in neuro-psychopharmacology and biological psychiatry, 2023; 123: 110695.
31. ORGANIZAÇÃO PAN-AMERICANA DA SAÚDE. Transtorno do espectro autista. Disponivel em: https ://www.paho.org/pt/topicos/transtorno-do-espectro-autista. Acesso em: 30 maio.2023.
32. PELLICANO E, et al. What should autism research focus upon? Community views and priorities from the United Kingdom. Autism, 2014; 18(7): 756-770.
33. REYNOLDS AM, et al. Randomized, placebo-controlled trial of ferrous sulfate to treat insomnia in children with autism spectrum disorders. Pediatric neurology, 2020; 104: 30–39.
34. RIEMANN, D. et al. The european insomnia guideline: An update on the diagnosis and treatment of insomnia 2023. Journal of sleep research, 2023; 32(6): 14035.
35. SINHA C, et al. Qualitative exploration toward the development of a parent-rated scale for insomnia in children with autism spectrum disorder. Journal of autism and developmental disorders, 2023; 54: 1792-1803.
36. SKONIECZNA-ŻYDECKA K, et al. The prevalence of insomnia and the link between iron metabolism genes polymorphisms, TF rs1049296 C>T, TF rs3811647 G>A, TFR rs7385804 A>C, HAMP rs10421768 A>G and sleep disorders in polish individuals with ASD. International journal of environmental research and public health, 2020; 17(2): 400.
37. SOCIEDADE BRASILEIRA DE PEDIATRIA. Transtorno do espectro do autismo. São Paulo: SBP, 2019. Disponível em: https ://www.sbp.com.br/fileadmin/user_upload/Ped._Desenvolvimento_-_21775b-MO_-_Transtorno_do_Espectro_do_Autismo.pdf. Acessado em: 30 de maio de 2023.
38. SOUDERS MC, et al. Sleep in Children with Autism Spectrum Disorder, 2018; 19(6): 34.
39. TAN-MACNEILL KM, et al. Barriers and facilitators to treating insomnia in children with autism spectrum disorder and other neurodevelopmental disorders: Parent and health care professional perspectives. Research in developmental disabilities, 2020; 107: 103792.
40. TAYLOR BJ, et al. Insomnia subtypes and clinical impairment in hospitalized children with autism spectrum disorder. Autism, 2020; 25(3): 656–666.
41. TESFAYE R, et al. Investigating the contributions of circadian pathway and insomnia risk genes to autism and sleep disturbances. Translational psychiatry, 2022; 12: 424.
42. VEATCH OJ, et al. Pleiotropic genetic effects influencing sleep and neurological disorders. the lancet. Neurology, 2017;16(2): 158-170.
43. WORLD HEALTH ORGANIZATION. Autism spectrum disorders. Disponível em: https ://www.who.int/news-room/fact-sheets/detail/autism-spectrum-disorders. Acesso em 30 maio. 2023.
44. XIONG M, et al. Efficacy of melatonin for insomnia in children with autism spectrum disorder: A meta-analysis. Neuropediatrics, 2023; 54(3): 167–173.