Fotobiomodulação para tratamento de mucosite oral em paciente infantojuvenil com síndrome de down e leucemia linfoblástica aguda

##plugins.themes.bootstrap3.article.main##

Fernanda Suely Barros Dantas
Tácio Fragoso Pereira
Luis Henrique Guedes de Andrade Lima
Katarina Haluli Janô da Veiga Pessôa
Jefferson Jorge Morais de Souza
Mariana de Moraes Corrêa Perez
Elaine da Silva Torres
Alessandra de Albuquerque Tavares Carvalho
William Alves de Melo Junior

Resumo

Objetivo: Relatar o caso clínico com uso da Fotobiomodulação (FBM) no tratamento de mucosite oral (MO) em uma paciente de 15 anos, com síndrome de Down (SD) e leucemia linfóide aguda (LLA), diagnosticada com LLA, o tratamento realizado e conclusão do caso. Detalhamento do Caso: Paciente branca, sexo feminino, 15 anos, diagnosticada com LLA e em tratamento quimioterápico com metotrexato em altas doses, desenvolveu MO, manifestando lesões orais dolorosas que dificultavam a alimentação. Como tratamento iniciou-se a terapia com FBM, ajustando a abordagem conforme a colaboração variável da paciente. Após algumas sessões, observou-se uma melhora significativa na cicatrização das lesões e na redução da dor, permitindo a retomada da alimentação oral sem desconforto significativo. Considerações Finais: A experiência clínica observada neste estudo sublinha a relevância e importância de se utilizar a FBM como uma intervenção valiosa para o manejo da MO em pacientes vulneráveis, incluindo também pacientes com SD e em tratamento quimioterápico.

##plugins.themes.bootstrap3.article.details##

Como Citar
DantasF. S. B., PereiraT. F., LimaL. H. G. de A., PessôaK. H. J. da V., SouzaJ. J. M. de, PerezM. de M. C., TorresE. da S., CarvalhoA. de A. T., & Melo JuniorW. A. de. (2025). Fotobiomodulação para tratamento de mucosite oral em paciente infantojuvenil com síndrome de down e leucemia linfoblástica aguda. Revista Eletrônica Acervo Saúde, 25, e18575. https://doi.org/10.25248/reas.e18575.2025
Seção
Estudos de Caso

Referências

1. AL-ANSARI S, et al. Oral mucositis induced by anticancer therapies. Current oral health reports, 2015; 2: 202-211.

2. AMADORI F, et al. Low-level laser therapy for treatment of chemotherapy-induced oral mucositis in childhood: a randomized double-blind controlled study. Lasers in medical science, 2016; 31: 1231-1236.

3. AMARO JS, et al. Fotobiomodulação como tratamento auxiliar de mucosite oral em pacientes submetidos a tratamentos antineoplásicos: revisão integrativa. Research, Society and Development, 2022; 11(8): e15511830827.

4. BASSO FG, et al. Biomodulation of inflammatory cytokines related to oral mucositis by low‐level laser therapy. Photochemistry and photobiology, 2015; 91(4): 952-956.

5. CHIANG JC, et al. Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro. Nature communications, 2018; 9(1): 5180.

6. CHUNG H, et al. The nuts and bolts of low-level laser (light) therapy. Annals of biomedical engineering, 2012; 40: 516-533.

7. CRUZ LB, et al. Influence of low‐energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy. Pediatric blood & cancer, 2007; 48(4): 435-440.

8. DE CASTRO JFL, et al. Low-level laser in prevention and treatment of oral mucositis in pediatric patients with acute lymphoblastic leukemia. Photomedicine and Laser surgery, 2013; 31(12): 613-618.

9. GOBBO M, et al. Multicenter randomized, double‐blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. Pediatric blood & cancer, 2018; 65(8): e27098.

10. KUHN A, et al. Low-level infrared laser therapy in chemotherapy-induced oral mucositis: a randomized placebo-controlled trial in children. Journal of pediatric hematology/oncology, 2009; 31(1): 33-37.

11. LAURENT AP, KOTECHA RS, MALINGE S. Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome. Leukemia, 2020; 34(8): 1984-1999.

12. LIAO W, LIU Y. Treatment outcomes in children with Acute lymphoblastic leukemia with versus without coexisting Down's syndrome: a systematic review and meta-analysis. Medicine, 2020; 99(29): e21015.

13. MAZHARI F, SHIRAZI AS, SHABZENDEHDAR M. Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta‐analysis. Pediatric Blood & Cancer, 2019; 66(3): e27403.

14. MURPHY BR, et al. Development of acute lymphoblastic leukemia following treatment for acute myeloid leukemia in children with Down syndrome: A case report and retrospective review of Children's Oncology Group acute myeloid leukemia trials. Pediatric blood & cancer, 2019; 66(8): e27700.

15. PERALTA-MAMANI M, et al. Low-level laser therapy dosimetry most used for oral mucositis due to radiotherapy for head and neck cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 2019; 138: 14-23.

16. REDMAN MG, HARRIS K, PHILLIPS BS. Low-level laser therapy for oral mucositis in children with cancer. Archives of Disease in Childhood, 2022; 107(2): 128-133.

17. REYAD FA, ELSAYED NM, EL CHAZLI Y. Photobiomodulation for chemotherapy‐induced oral mucositis in leukemic children: A randomized controlled clinical trial. Oral diseases, 2023; 29(5): 2239-2247.

18. REZK-ALLAH SS, et al. Effect of low-level laser therapy in treatment of chemotherapy induced oral mucositis. Journal of lasers in medical sciences, 2019; 10(2): 125.

19. ROBERTS KG. Genetics and prognosis of ALL in children vs adults. Hematology 2014, The American Society of Hematology Education Program Book, 2018; 2018(1): 137-145.

20. SONIS ST, et al. Perspectives on cancer therapy‐induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer: Interdisciplinary International Journal of the American Cancer Society, 2004; 100(S9): 1995-2025.

21. SUNG L, et al. Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation. BMJ supportive & palliative care, 2017; 7(1): 7-16.

22. ZIPURSKY A. Susceptibility to leukemia and resistance to solid tumors in Down syndrome. Pediatric research, 2000; 47(6): 704.