Modulação da barreira hematoencefálica por ultrassom focado e neuroinflamação
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Resumo
Objetivo: Avaliar o impacto da modulação da barreira hematoencefálica por ultrassom focado na neuroinflamação, com foco nas implicações terapêuticas para doenças neurológicas e neurodegenerativas. Métodos: Revisão integrativa no PubMed Central (PMC). Foram selecionados inicialmente 587 artigos. A partir de critérios rigorosos de inclusão e exclusão, utilizando apenas artigos em inglês no período de 2020 a 2024, foram selecionados 17 artigos. Resultados: O uso de ultrassonografia focada influencia diretamente processos neuroinflamatórios, por meio da indução da abertura temporária da barreira hematoencefálica, promovendo efeito de aumento da penetração de terapia imunológicas, farmacológicas e, ainda, processo depurativo de proteínas com estímulo celular e neurogênico, permitindo ainda a melhora cognitiva, sem lesão ou morte celular associada. Considerações finais: O ultrassom focado é uma abordagem promissora e simples, permitindo seu uso em processos neurodegenerativos, neuroinflamatórios, neuro-oncológicos e distúrbios neuromotores. Entretanto, novos estudos devem ser realizados a fim de evidenciar o máximo potencial terapêutico dessa categoria terapêutica.
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