A nanotecnologia no tratamento de feridas em pacientes com Diabetes Mellitus
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Mar 31, 2025
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Resumo
Objetivo: Verificar a efetividade da nanotecnologia no processo de cicatrização de feridas em pacientes diabéticos. Métodos: Revisão integrativa cujas bases de dados utilizadas foram PubMed, Scopus e EMBASE. Utilizou-se como pergunta norteadora: Qual a efetividade do uso da nanotecnologia na cicatrização de feridas em pacientes com diabetes mellitus?. Resultados: Inicialmente, foram selecionados 132 artigos, restando 120 após verificação de duplicação; os títulos e resumos foram analisados e 72 trabalhos foram excluídos. Por fim, 26 artigos foram excluídos após a leitura do artigo completo. Admitiram-se, para a análise final, 22 artigos. Considerações finais: Os estudos in vivo e o ensaio clínico mostraram que diversas nanotecnologias são potenciais promissores no tratamento de feridas em pacientes com DM. No entanto, são necessários mais estudos clínicos que irão realmente avaliar a efetividade dessas tecnologias a fim de se terem novas alternativas para o tratamento dessa condição.
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Como Citar
CostaJ. de A., Dantas FilhoF. J. L., CoelhoV. F., MagalhãesV. D., PassosA. C. de B., FontelesM. M. de F., & RomeroN. R. (2025). A nanotecnologia no tratamento de feridas em pacientes com Diabetes Mellitus. Revista Eletrônica Acervo Saúde, 25, e19130. https://doi.org/10.25248/reas.e19130.2025
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Referências
1. AASY NKA, et al. Concurrent Tissue Engineering for Wound Healing in Diabetic Rats Utilizing Dual Actions of Green Synthesized CuO NPs Prepared from Two Plants Grown in Egypt. Int J Nanomedicine, 2023; 18: 1927-1947.
2. ALENCAR MSM, et al. Análise da produção científica brasileira sobre nanotecnologia e saúde. Rev Eletr Comun Inf Inov Saúde. 2017;11(1):1-16.
3. ANAND S, et al. Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats. Pharmaceuticals (Basel). 2022 28;15(3):302.
4. ANDLEEB A, et al. Hydrogel patch with pretreated stem cells accelerates wound closure in diabetic rats. Biomater Adv. 2022; 142: 213150.
5. BAI Q, et al. Potential applications of nanomaterials and technology for diabetic wound healing. Int J Nanomedicine. 2020; 15:9717-43.
6. BURGESS JL, et al. Diabetic Wound-Healing Science. Medicina (Kaunas). 2021 Oct 8;57(10):1072.
7. CARVALHO VF, et al. Feridas em pacientes diabéticos. Revista De Medicina, 2010; 89(3-4), 164-169.
8. COLE JB e FLOREZ JC. Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol, 2020;16(7):377-390.
9. CORREA VLR, et al. Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats. Int J Biol Macromol. 2020 Nov 1;162:1465-1475.
10. El-LAKANY SA, et al. Graphene oxide crosslinked-zein nanofibrous scaffolds for prominent Cu-adsorption as tissue regeneration promoters in diabetic rats: Nanofibers optimization and in vivo assessment. Int J Pharm. 2020 Nov 30;590:119919.
11. HAN BW, et al. Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing. Tissue Eng Part A. 2015; 21(17-18): 2366-78.
12. HEKMAT M, et al Combined Use of Photobiomodulation and Curcumin-Loaded Iron Oxide Nanoparticles Significantly Improved Wound Healing in Diabetic Rats Compared to Either Treatment Alone. J Lasers Med Sci. 2023 Jun 12;14:e18.
13. INSTITUTO BUTANTAN. 2021. In: Da pesquisa in vitro ao produto final: conheça o passo a passo do desenvolvimento de novos medicamentos. Disponível em: https://butantan.gov.br/noticias/da-pesquisa-in-vitro-ao-produto-final-conheca-o-passo-a-passo-do-desenvolv imento-de-novos-medicamentos. Acessado em: 08 de agosto de 2024.
14. JEONG S-H, et al. Accelerated wound healing with an ionic patch assisted by a triboelectric nanogenerator, Nano Energy, Volume 79, 2021, ISSN 2211-2855.
15. KHAZAELIi P, et al. Preparation of PLA/chitosan nanoscaffolds containing cod liver oil and experimental diabetic wound healing in male rats study. J Nanobiotechnology. 2020 Nov 30;18(1):176.
16. KEYKHAEE M, et al. Alginate/gum arabic-based biomimetic hydrogel enriched with immobilized nerve growth factor and carnosine improves diabetic wound regeneration, Carbohydrate Polymers, Volume 321, 2023, ISSN 0144-8617.
17. PANDA DS, et al. Berberine Encapsulated Lecithin-Chitosan Nanoparticles as Innovative Wound Healing Agent in Type II Diabetes. Pharmaceutics. 2021 Aug 4;13(8):1197.
18. SAHA K, et al. Ameliorative effects of clindamycin - nanoceria conjugate: A ROS responsive smart drug delivery system for diabetic wound healing study. J Trace Elem Med Biol. 2023; 75: 127107.
19. SANTOS CMC, et al. The PICO strategy for the research question construction and evidence search. Revista latino-americana de enfermagem, 2007; 15: 508-511.
20. SHAHVERDI S, et al. Fabrication and structure analysis of poly(lactide-co-glycolic acid)/silk fibroin hybrid scaffold for wound dressing applications. Int J Pharm. 2014 Oct 1;473(1-2):345-55.
21. SHIVAM K, et al. Graphene quantum dots-hybrid hydrogel as an avant-garde biomimetic scaffold for diabetic wound healing. Biomater Adv. 2023; 149: 213395.
22. TEAIMA M.H, et al.Wound healing activities of polyurethane modified chitosan nanofibers loaded with different concentrations of linezolid in an experimental model of diabetes, Journal of Drug Delivery Science and Technology, 2022; 67, ISSN 1773-2247.
23. WANG H, et al. Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity. Adv Healthc Mater. 2023 Dec;12(31):e2301683.
24. YAHIA EA, et al. Avaliação quantitativa da cicatrização de feridas em pés diabéticos usando curativo à base de nanoprata de hidrogel versus curativo tradicional: um estudo prospectivo randomizado de controle Junho de 2021. Revista Paquistanesa de Ciências Médicas e da Saúde 15(6):1571-1574.
25. YOUNIS, et al. Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions. Mar Drugs. 2022 Jan 6;20(1):56.
26. WEI X, et al. Enzyme-responsive nanospheres target senescent cells for diabetic wound healing by employing chemodynamic therapy. Acta Biomater. 2023; 172: 407-422.
27. ZAN X, et al. Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing. Adv Sci (Weinh). 2024; 11(9): e2305405.
28. ZEHRA M, et al. Oxygen Generating Polymeric Nano Fibers That Stimulate Angiogenesis and Show Efficient Wound Healing in a Diabetic Wound Model. Int J Nanomedicine. 2020;15: 3511-3522.
29. ZGHEIB C, et al. Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment. J Am Coll Surg. 2019; 228(1): 107-115.
2. ALENCAR MSM, et al. Análise da produção científica brasileira sobre nanotecnologia e saúde. Rev Eletr Comun Inf Inov Saúde. 2017;11(1):1-16.
3. ANAND S, et al. Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats. Pharmaceuticals (Basel). 2022 28;15(3):302.
4. ANDLEEB A, et al. Hydrogel patch with pretreated stem cells accelerates wound closure in diabetic rats. Biomater Adv. 2022; 142: 213150.
5. BAI Q, et al. Potential applications of nanomaterials and technology for diabetic wound healing. Int J Nanomedicine. 2020; 15:9717-43.
6. BURGESS JL, et al. Diabetic Wound-Healing Science. Medicina (Kaunas). 2021 Oct 8;57(10):1072.
7. CARVALHO VF, et al. Feridas em pacientes diabéticos. Revista De Medicina, 2010; 89(3-4), 164-169.
8. COLE JB e FLOREZ JC. Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol, 2020;16(7):377-390.
9. CORREA VLR, et al. Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats. Int J Biol Macromol. 2020 Nov 1;162:1465-1475.
10. El-LAKANY SA, et al. Graphene oxide crosslinked-zein nanofibrous scaffolds for prominent Cu-adsorption as tissue regeneration promoters in diabetic rats: Nanofibers optimization and in vivo assessment. Int J Pharm. 2020 Nov 30;590:119919.
11. HAN BW, et al. Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing. Tissue Eng Part A. 2015; 21(17-18): 2366-78.
12. HEKMAT M, et al Combined Use of Photobiomodulation and Curcumin-Loaded Iron Oxide Nanoparticles Significantly Improved Wound Healing in Diabetic Rats Compared to Either Treatment Alone. J Lasers Med Sci. 2023 Jun 12;14:e18.
13. INSTITUTO BUTANTAN. 2021. In: Da pesquisa in vitro ao produto final: conheça o passo a passo do desenvolvimento de novos medicamentos. Disponível em: https://butantan.gov.br/noticias/da-pesquisa-in-vitro-ao-produto-final-conheca-o-passo-a-passo-do-desenvolv imento-de-novos-medicamentos. Acessado em: 08 de agosto de 2024.
14. JEONG S-H, et al. Accelerated wound healing with an ionic patch assisted by a triboelectric nanogenerator, Nano Energy, Volume 79, 2021, ISSN 2211-2855.
15. KHAZAELIi P, et al. Preparation of PLA/chitosan nanoscaffolds containing cod liver oil and experimental diabetic wound healing in male rats study. J Nanobiotechnology. 2020 Nov 30;18(1):176.
16. KEYKHAEE M, et al. Alginate/gum arabic-based biomimetic hydrogel enriched with immobilized nerve growth factor and carnosine improves diabetic wound regeneration, Carbohydrate Polymers, Volume 321, 2023, ISSN 0144-8617.
17. PANDA DS, et al. Berberine Encapsulated Lecithin-Chitosan Nanoparticles as Innovative Wound Healing Agent in Type II Diabetes. Pharmaceutics. 2021 Aug 4;13(8):1197.
18. SAHA K, et al. Ameliorative effects of clindamycin - nanoceria conjugate: A ROS responsive smart drug delivery system for diabetic wound healing study. J Trace Elem Med Biol. 2023; 75: 127107.
19. SANTOS CMC, et al. The PICO strategy for the research question construction and evidence search. Revista latino-americana de enfermagem, 2007; 15: 508-511.
20. SHAHVERDI S, et al. Fabrication and structure analysis of poly(lactide-co-glycolic acid)/silk fibroin hybrid scaffold for wound dressing applications. Int J Pharm. 2014 Oct 1;473(1-2):345-55.
21. SHIVAM K, et al. Graphene quantum dots-hybrid hydrogel as an avant-garde biomimetic scaffold for diabetic wound healing. Biomater Adv. 2023; 149: 213395.
22. TEAIMA M.H, et al.Wound healing activities of polyurethane modified chitosan nanofibers loaded with different concentrations of linezolid in an experimental model of diabetes, Journal of Drug Delivery Science and Technology, 2022; 67, ISSN 1773-2247.
23. WANG H, et al. Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity. Adv Healthc Mater. 2023 Dec;12(31):e2301683.
24. YAHIA EA, et al. Avaliação quantitativa da cicatrização de feridas em pés diabéticos usando curativo à base de nanoprata de hidrogel versus curativo tradicional: um estudo prospectivo randomizado de controle Junho de 2021. Revista Paquistanesa de Ciências Médicas e da Saúde 15(6):1571-1574.
25. YOUNIS, et al. Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions. Mar Drugs. 2022 Jan 6;20(1):56.
26. WEI X, et al. Enzyme-responsive nanospheres target senescent cells for diabetic wound healing by employing chemodynamic therapy. Acta Biomater. 2023; 172: 407-422.
27. ZAN X, et al. Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing. Adv Sci (Weinh). 2024; 11(9): e2305405.
28. ZEHRA M, et al. Oxygen Generating Polymeric Nano Fibers That Stimulate Angiogenesis and Show Efficient Wound Healing in a Diabetic Wound Model. Int J Nanomedicine. 2020;15: 3511-3522.
29. ZGHEIB C, et al. Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment. J Am Coll Surg. 2019; 228(1): 107-115.