Impacto do uso de vape no risco de câncer de bexiga: avaliação das exposições a carcinógenos e implicações para a saúde dos usuários
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Resumo
Objetivo: Investigar a relação entre o uso de vape e o risco de câncer de bexiga, comparando-o com o tabagismo tradicional e explorando mecanismos biológicos subjacentes. Métodos: Revisão integrativa com pesquisa na base PubMed Central (PMC), utilizando termos como "vaping", "vapers", "e-cigarettes", "carcinogens", "bladder cancer" e "carcinogenesis". Foram selecionados 18 artigos para análise. Resultados: Embora o vape seja promovido como alternativa menos nociva ao cigarro tradicional, ele não está isento de riscos. Níveis elevados de biomarcadores urinários associados à carcinogênese foram encontrados em usuários de vapes e cigarros tradicionais. Substâncias tóxicas do tabaco favorecem mutações e interrompem o reparo do DNA, contribuindo para o câncer de bexiga. Considerações finais: Destaca-se a necessidade de campanhas educacionais para reduzir o consumo de substâncias carcinogênicas e políticas públicas enfatizando os riscos do vape. Estudos sobre os impactos do vape ainda estão em fase inicial, tornando essencial a realização de pesquisas longitudinais para melhor compreender a relação entre o uso de cigarros eletrônicos e o câncer de bexiga.
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Referências
2. BESARATINIA A e TOMMASI S. Electronic cigarettes: The road ahead. Preventive Medicine, 2014; 66: 101016.
3. BJURLIN MA, et al. Carcinogen Biomarkers in the Urine of Electronic Cigarette Users and Implications for the Development of Bladder Cancer: A Systematic Review. European Urology Oncology, 2021; 4: 766-783.
4. CABALLERO JM, et al. Environmental Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North-Eastern Spain. Journal of Environmental and Public Health, 2022; 1051046.
5. CANISTRO D, et al. E-cigarettes induce toxicological effects that can raise the cancer risk. Scientific Reports, 2017; 7(1): 2028.
6. COX S, et al. E-cigarette puffing patterns associated with high and low nicotine e-liquid strength: effects on toxicant and carcinogen exposure. BMC Public Health, 2016; 16: 1-9.
7. CUMBERBATCH MG, et al. The role of tobacco smoke in bladder and kidney carcinogenesis: a comparison of exposures and meta-analysis of incidence and mortality risks. European Urology, 2016; 70(3): 458-466.
8. FENG L, et al. Comparison of bladder carcinogenesis biomarkers in the urine of traditional cigarette users and e-cigarette users. Frontiers in Public Health, 2024; 12: 1385628.
9. GAUR S e AGNIHOTRI R. Health Effects of Trace Metals in Electronic Cigarette Aerosols—a Systematic Review. Biological Trace Element Research, 2018; 188: 295–315.
10. HAMAD SH, et al. Pilot study to detect genes involved in DNA damage and cancer in humans: potential biomarkers of exposure to e-cigarette aerosols. Genes, 2021; 12(3): 448.
11. IZQUIERDO-CONDOY JS, et al. Direct health implications of e-cigarette use: a systematic scoping review with evidence assessment. Frontiers in Public Health, 2024; 12: 1427752.
12. JIN F, et al. Tobacco-specific carcinogens induce hypermethylation, DNA adducts and DNA damage in Bladder Cancer. Cancer Prev Res (Phila). Author manuscript, 2017; 10(10): 588–597.
13. KANG JC e VALERIO JR LG. Investigating DNA adduct formation by flavor chemicals and tobacco byproducts in electronic nicotine delivery system (ENDS) using in silico approaches. Toxicology and Applied Pharmacology, 2020; 398: 115026.
14. LACOMBE L, et al. Phase II Drug-Metabolizing Polymorphisms and Smoking Predict Recurrence of Non-Muscle-Invasive Bladder Cancer: A Gene–Smoking Interaction. Cancer Prevention Research, 2016; 9(2): 101158.
15. LEE HW, et al. E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proceedings of the National Academy of Sciences, 2018; 115(7): 1560-1569.
16. LEON ME, et al. European code against cancer: tobacco and cancer. Cancer Epidemiology, 2015; 39: 20-33.
17. LOHANI M, et al. Niacin deficiency modulates genes involved in cancer: Are smokers at higher risk? Journal of Cellular Biochemistry, 2018; 120(1): 232-242.
18. LORENZO-PARODI N, et al. Analysis of aromatic amines in human urine using comprehensive multi-dimensional gas chromatography-mass spectrometry (GCxGC-MS). International Journal of Hygiene and Environmental Health, 2024; 257: 114343.
19. MA B, et al. Recent studies on DNA adducts resulting from human exposure to tobacco smoke. Toxics, 2019; 7(1): 16.
20. MA W, et al. Can smoking cause differences in urine microbiome in male patients with bladder cancer? A retrospective study. Frontiers in Oncology, 2021; 11: 677605.
21. SAHU R, et al. E-cigarettes and associated health risks: an update on cancer potential. Advances in Respiratory Medicine, 2023; 91(6): 516-531.
22. TANG MS, et al. Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice. Proceedings of the National Academy of Sciences, 2019; 116(43): 21727-21731.
23. WOJTCZYK-MIASKOWSKA A e SCHLICHTHOLZ B. Tobacco carcinogens and the methionine metabolism in human bladder cancer. Mutation Research/Reviews in Mutation Research, 2019; 782: 108281.
24. ZULKIFLI A, et al. Electronic cigarettes: a systematic review of available studies on health risk assessment. Reviews on Environmental Health, 2018; 33(1): 43-52.