Manifestações orofaciais associadas à anemia falciforme
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May 14, 2025
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Resumo
Objetivo: Revisar as principais manifestações orofaciais comumente associadas à anemia falciforme (AF), enfatizando as características clínicas e radiográficas dessas alterações, sua fisiopatologia e sua relação com complicações sistêmicas. Revisão Bibliográfica: A doença falciforme (DF) é um termo usado para descrever um grupo de distúrbios hematológicos hereditários caracterizados pela falcização dos eritrócitos. Vários fatores associados à doença aumentam a suscetibilidade a alterações nos tecidos orais. Considerações Finais: Conclui-se que vários fatores associados à AF podem influenciar no desenvolvimento de algumas manifestações orais, impactando diretamente na saúde bucal e na qualidade de vida. Assim, é fundamental que o cirurgião-dentista conheça essas características clínicas, fisiopatológicas e radiográficas para o correto manejo e abordagem do paciente com anemia falciforme.
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Como Citar
BastosA. G. R., PintoK. M. M. da C., PintoC. G. V. F., BarrosP. R. de S., OrsiniM., FerreiraD. de C., MendesV. L. D. da C., & DiasL. A. (2025). Manifestações orofaciais associadas à anemia falciforme. Revista Eletrônica Acervo Saúde, 25(5), e20203. https://doi.org/10.25248/reas.e20203.2025
Seção
Revisão Bibliográfica
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Referências
1. ACHARYA S, et al. Oral and dental considerations in the management of sickle cell anemia. Int J Clin Pediatr Dent. 2015;8(2):141-144.
2. ANDREWS CH, et al. Sickle cell anemia: an etiological factor in pulpal necrosis. J Endod. 1983;9(6):249-252.
3. AROWOJOLU MO, SAVAGE KO. Alveolar bone patterns in sickle cell anemia and non-sickle cell anemia adolescent Nigerians: a comparative study. J Periodontol. 1997;68(3): 225-228.
4. CARVALHO HLCC, et al. Are sickle cell anaemia and sickle cell trait predictive factors for periodontal disease? A cohortstudy. J Periodontal Res. 2016;51(5):622-629.
5. CARVALHO HLCC, et al. Are dental and jaw changes more prevalent in a Brazilian population with sickle cell anemia? Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(1):76-84.
6. CHEKROUN M, et al. Oral manifestations of sickle cell disease. Br Dent J. 2019;226(1):27-31.
7. COLLINS WO, et al. Extramedullary hematopoiesis of the paranasal sinuses in sickle cell disease. Otolaryngol Head Neck Surg 2005;132(6):954–956.
8. COSTA CPS, et al. Association between sickle cell anemia and pulp necrosis. J Endod. 2013;39(2):177–181.
9. COSTA CPS, et al. Biological factors associating pulp necrosis and sickle cell anemia. Oral Dis. 2020;26(7):1558-1565.
10. COSTA CPS, et al. Is there bacterial infection in the intact crowns of teeth with pulp necrosis of sickle cell anaemia patients? A case series study nested in a cohort. Int Endod J. 2021;54(6):817-825.
11. COSTA SA, et al. Mechanisms underlying the adaptive pulp and jaw bone trabecular changes in sickle cell anemia. Oral Dis. 2023;29(2):786-795.
12. FERNANDES MLMF, et al. Caries prevalence and impact on oral health-related quality of life in children with sickle cell disease: cross-sectional study. BMC Oral Health. 2015;18:15:68.
13. FERREIRA SBP, et al. Periapical cytokine expression in sickle cell disease. J Endod. 2015;41(3):358-362.
14. FERREIRA SBP, et al. Sickle cell anemia in Brazil: personal, medical and endodontic patterns. Braz Oral Res. 2016;30(1):S1806-83242016000100255.
15. FUKUDA JT, et al. Acquisition of mutans streptococci and caries prevalence in pediatric sickle cell anemia patients receiving long-term antibiotic therapy. Pediatr Dent. 2005;27(3):186-190.
16. GIRGIS S, et al. Orofacial manifestations of sickle cell disease: implications for dental clinicians. Br Dent J. 2021;230(3):143-147.
17. HONG L, et al. Association between enamel hypoplasia and dental caries in primary second molars: a cohort study. Caries Res. 2009;43:345-353.
18. HSU LL, FAN-HSU J. Evidence-based dental management in the new era of sickle cell disease: A scoping review. J AmDent Assoc. 2020;151(9):668-677.
19. ITO K, et al. Hypoxic condition promotes differentiation and mineralization of dental pulp cells in vivo. Int Endod J. 2014;48(2):115-123.
20. JAVED F, et al. Orofacial manifestations in patients with sickle cell disease. Am J Med Sci 2013;345(3):234–237.
21. KAKKAR M, et al. Orofacial manifestation and dental management of sickle cell disease: A scoping review. Anemia. 2021:5556708.
22. KAVADIA-TSATALA S, et al. Mandibular lesions of vasoclusive origin in sickle cell hemoglobinopathy. Odontology. 2004;92(1):68-72.
23. KAWAR N, et al. Sickle cell disease: An overview of orofacial and dental manifestations. Dis Mon. 2018;64(6):290-295.
24. KAYA AD, et al. Pupal necrosis witch sickle cell anaemia. Int Endod J. 2004;37(9): 602-606.
25. KELLEHER M, et al. Oral complications associated with sickle cell anemia: a review and case report. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 1996;82(2):225-228.
26. LI L, et al. Hypoxia promotes mineralization of human dental pulp cells. J Endod. 2011;37(6):799–802.
27. LOPES CMI, et al. Enamel defects and tooth eruption disturbances in children with sickle cell anemia. Braz Oral Res. 2018;13;32:e87.
28. LOPES CMI, et al. Occlusal disorders in patients with sickle cell disease: Critical literature review. J Clin Pediatr Dent. 2021;45(2):117-122.
29. MAHMOUD MO, et al. Associations between sickle cell anemia and periodontal diseases among 12- to 16-year-old Sudanese children. Oral Health Prev Dent. 2013;11(4):375–381.
30. MANDAL AK, et al. Sickle cell hemoglobin. SubcellBiochem. 2020;94:297-322.
31. MCCAVIT, TL. Sickle cell disease. Pediatr Rev. 2012;33(5):195-206.
32. MENDES PHC, et al. Orofacial manifestations in patients with sickle cell anaemia. Quintessence Int. 2011;42(8):701-709.
33. MENKA K, et al. Analyzing effects of sickle cell disease on morphometric and cranial growth in Indian population. J Pharm Bioallied Sci. 2021;13(Suppl 2):S1402-S1405.
34. BRASIL. Manual doMinistério da Saúde Doença falciforme: saúde bucal: prevenção e cuidado. 2014. Disponível em:https://bvsms.saude.gov.br/bvs/publicacoes/doenca_falciforme_saude_bucal_prevencao.pdf
35. BRASIL. Manual do Ministério da Saúde Doença falciforme: conhecer para cuidar. 2015. Disponível em:https://bvsms.saude.gov.br/bvs/publicacoes/caderno_informacao_sangue_hemoderivados_5ed.pdf
36. PASSOS CP, et al. Sickle cell disease does not predispose to caries or periodontal disease. SpecCareDentist. 2012;32(2):55-60.
37. PATTON LL, et al. Mandibular osteomyelitis in a patient with sickle cell anemia: report of case. J Am Dent Assoc. 1990;121(5):602-604.
38. REES DC, et al. Determinants of severity in sickle cell disease. Blood Rev. 2022;56:100983
39. SAITO N, et al. Clinical and radiographic manifestations of sickle cell disease in the head and neck. RadioGraphics. 2010;30(4):1021-1034.]
40. SHROYER JV, et al. Osteomyelitis of the mandible as a result of sickle cell disease. Oral Surg Oral Med Oral Pathol. 1991;72(1):25-28.
41. SONI NN. Microradiographic study of dental tissues in sickle-cell anaemia. Arch Oral Biol. 1966;11(6):561-564
42. SOUZA SFC, et al. Association of sickle cell haemoglobinopathies with dental and jaw bone abnormalities. Oral Dis 2018;24(3):393-403.
43. SOUZA SFC, et al. Healthy dental pulp oxygen saturation rates in subjects with homozygous sickle cell anemia: A cross-sectional study nested in a cohort. J Endod. 2017;43(12):1997-2000.
44. TAYLOR LB, et al. Casamassimo PS. Sickle cell anemia: A review of the dental concerns and a retrospective study of dental and bony changes. Spec Care Dentist. 1995:15(1):38-42.
45. ZHANG D, et al. Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology. Blood. 2016;127(7):801-810.
2. ANDREWS CH, et al. Sickle cell anemia: an etiological factor in pulpal necrosis. J Endod. 1983;9(6):249-252.
3. AROWOJOLU MO, SAVAGE KO. Alveolar bone patterns in sickle cell anemia and non-sickle cell anemia adolescent Nigerians: a comparative study. J Periodontol. 1997;68(3): 225-228.
4. CARVALHO HLCC, et al. Are sickle cell anaemia and sickle cell trait predictive factors for periodontal disease? A cohortstudy. J Periodontal Res. 2016;51(5):622-629.
5. CARVALHO HLCC, et al. Are dental and jaw changes more prevalent in a Brazilian population with sickle cell anemia? Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(1):76-84.
6. CHEKROUN M, et al. Oral manifestations of sickle cell disease. Br Dent J. 2019;226(1):27-31.
7. COLLINS WO, et al. Extramedullary hematopoiesis of the paranasal sinuses in sickle cell disease. Otolaryngol Head Neck Surg 2005;132(6):954–956.
8. COSTA CPS, et al. Association between sickle cell anemia and pulp necrosis. J Endod. 2013;39(2):177–181.
9. COSTA CPS, et al. Biological factors associating pulp necrosis and sickle cell anemia. Oral Dis. 2020;26(7):1558-1565.
10. COSTA CPS, et al. Is there bacterial infection in the intact crowns of teeth with pulp necrosis of sickle cell anaemia patients? A case series study nested in a cohort. Int Endod J. 2021;54(6):817-825.
11. COSTA SA, et al. Mechanisms underlying the adaptive pulp and jaw bone trabecular changes in sickle cell anemia. Oral Dis. 2023;29(2):786-795.
12. FERNANDES MLMF, et al. Caries prevalence and impact on oral health-related quality of life in children with sickle cell disease: cross-sectional study. BMC Oral Health. 2015;18:15:68.
13. FERREIRA SBP, et al. Periapical cytokine expression in sickle cell disease. J Endod. 2015;41(3):358-362.
14. FERREIRA SBP, et al. Sickle cell anemia in Brazil: personal, medical and endodontic patterns. Braz Oral Res. 2016;30(1):S1806-83242016000100255.
15. FUKUDA JT, et al. Acquisition of mutans streptococci and caries prevalence in pediatric sickle cell anemia patients receiving long-term antibiotic therapy. Pediatr Dent. 2005;27(3):186-190.
16. GIRGIS S, et al. Orofacial manifestations of sickle cell disease: implications for dental clinicians. Br Dent J. 2021;230(3):143-147.
17. HONG L, et al. Association between enamel hypoplasia and dental caries in primary second molars: a cohort study. Caries Res. 2009;43:345-353.
18. HSU LL, FAN-HSU J. Evidence-based dental management in the new era of sickle cell disease: A scoping review. J AmDent Assoc. 2020;151(9):668-677.
19. ITO K, et al. Hypoxic condition promotes differentiation and mineralization of dental pulp cells in vivo. Int Endod J. 2014;48(2):115-123.
20. JAVED F, et al. Orofacial manifestations in patients with sickle cell disease. Am J Med Sci 2013;345(3):234–237.
21. KAKKAR M, et al. Orofacial manifestation and dental management of sickle cell disease: A scoping review. Anemia. 2021:5556708.
22. KAVADIA-TSATALA S, et al. Mandibular lesions of vasoclusive origin in sickle cell hemoglobinopathy. Odontology. 2004;92(1):68-72.
23. KAWAR N, et al. Sickle cell disease: An overview of orofacial and dental manifestations. Dis Mon. 2018;64(6):290-295.
24. KAYA AD, et al. Pupal necrosis witch sickle cell anaemia. Int Endod J. 2004;37(9): 602-606.
25. KELLEHER M, et al. Oral complications associated with sickle cell anemia: a review and case report. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 1996;82(2):225-228.
26. LI L, et al. Hypoxia promotes mineralization of human dental pulp cells. J Endod. 2011;37(6):799–802.
27. LOPES CMI, et al. Enamel defects and tooth eruption disturbances in children with sickle cell anemia. Braz Oral Res. 2018;13;32:e87.
28. LOPES CMI, et al. Occlusal disorders in patients with sickle cell disease: Critical literature review. J Clin Pediatr Dent. 2021;45(2):117-122.
29. MAHMOUD MO, et al. Associations between sickle cell anemia and periodontal diseases among 12- to 16-year-old Sudanese children. Oral Health Prev Dent. 2013;11(4):375–381.
30. MANDAL AK, et al. Sickle cell hemoglobin. SubcellBiochem. 2020;94:297-322.
31. MCCAVIT, TL. Sickle cell disease. Pediatr Rev. 2012;33(5):195-206.
32. MENDES PHC, et al. Orofacial manifestations in patients with sickle cell anaemia. Quintessence Int. 2011;42(8):701-709.
33. MENKA K, et al. Analyzing effects of sickle cell disease on morphometric and cranial growth in Indian population. J Pharm Bioallied Sci. 2021;13(Suppl 2):S1402-S1405.
34. BRASIL. Manual doMinistério da Saúde Doença falciforme: saúde bucal: prevenção e cuidado. 2014. Disponível em:https://bvsms.saude.gov.br/bvs/publicacoes/doenca_falciforme_saude_bucal_prevencao.pdf
35. BRASIL. Manual do Ministério da Saúde Doença falciforme: conhecer para cuidar. 2015. Disponível em:https://bvsms.saude.gov.br/bvs/publicacoes/caderno_informacao_sangue_hemoderivados_5ed.pdf
36. PASSOS CP, et al. Sickle cell disease does not predispose to caries or periodontal disease. SpecCareDentist. 2012;32(2):55-60.
37. PATTON LL, et al. Mandibular osteomyelitis in a patient with sickle cell anemia: report of case. J Am Dent Assoc. 1990;121(5):602-604.
38. REES DC, et al. Determinants of severity in sickle cell disease. Blood Rev. 2022;56:100983
39. SAITO N, et al. Clinical and radiographic manifestations of sickle cell disease in the head and neck. RadioGraphics. 2010;30(4):1021-1034.]
40. SHROYER JV, et al. Osteomyelitis of the mandible as a result of sickle cell disease. Oral Surg Oral Med Oral Pathol. 1991;72(1):25-28.
41. SONI NN. Microradiographic study of dental tissues in sickle-cell anaemia. Arch Oral Biol. 1966;11(6):561-564
42. SOUZA SFC, et al. Association of sickle cell haemoglobinopathies with dental and jaw bone abnormalities. Oral Dis 2018;24(3):393-403.
43. SOUZA SFC, et al. Healthy dental pulp oxygen saturation rates in subjects with homozygous sickle cell anemia: A cross-sectional study nested in a cohort. J Endod. 2017;43(12):1997-2000.
44. TAYLOR LB, et al. Casamassimo PS. Sickle cell anemia: A review of the dental concerns and a retrospective study of dental and bony changes. Spec Care Dentist. 1995:15(1):38-42.
45. ZHANG D, et al. Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology. Blood. 2016;127(7):801-810.