Deficiência de Vitamina D e depressão pós-parto
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Jun 3, 2025
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Resumo
Objetivo: Investigar se a deficiência de vitamina D pode estar associada ao desenvolvimento da depressão pós-parto, com base em evidências científicas disponíveis. Métodos: Revisão Integrativa, realizada nas bases de dados PUBMED, BVS, SCIELO, MEDLINE E LILACS, com os Descritores em Saúde: “Postpartum Depression” AND “Vitamin D”. Após uma criteriosa avaliação, foram selecionados do total 15 artigos que compõem este estudo. Resultados: Os autores abordam que a deficiência de vitamina D possui uma grande conexão e está ligada diretamente com a depressão pós-parto, onde após a categorização dos estudos, constatou-se que 86,6% (n=13) obtiveram evidências positivas sobre o tema, destacando que a deficiência de vitamina D afeta diretamente a saúde mental das gestantes e puérperas. Assim, garantir níveis adequados de vitamina D durante a gestação pode ser uma estratégia preventiva importante, especialmente para mulheres com maior vulnerabilidade à depressão. Considerações finais: Conforme os dados apresentados, observa-se que a deficiência de vitamina D é um fator de risco significativo para a depressão puerperal, porém necessitando de estudos mais concisos para enfatizar este estudo.
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Como Citar
SilvaI. A., LopesF. L., & SousaM. N. A. de. (2025). Deficiência de Vitamina D e depressão pós-parto. Revista Eletrônica Acervo Saúde, 25(6), e20694. https://doi.org/10.25248/reas.e20694.2025
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Referências
1. ABEDI P, et al. The relationship between vitamin D and postpartum depression in reproductive-aged Iranian women. Journal of medicine and life, 2018; 11(4): 286.
2. ACCORTT EE, et al. Low prenatal vitamin D metabolite ratio and subsequent postpartum depression risk. Journal of Women's Health, 2021; 30(1): 113-120.
3. ACCORTT EE, et al. Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: Preliminary evidence for moderation by inflammatory cytokines. Archives of women's mental health, 2016; 19(2): 373-383.
4. ACCORTT EE, et al. Vitamin D deficiency and depressive symptoms in pregnancy are associated with adverse perinatal outcomes. Journal of Behavioral Medicine, 2018; 41(5): 680-689.
5. AGHAJAFARI F, et al. Vitamin D deficiency and antenatal and postpartum depression: a systematic review. Nutrients, 2018; 10(4): 478.
6. AL-SABAH R, et al. Antenatal Depression and its Associated Factors: Findings from Kuwait Birth Cohort Study. Journal of epidemiology and global health, 2024; 14(3): 847-859.
7. BATEINEH S e ATOUM MF. Association between Vitamin D Levels During Pregnancy and Postpartum Depression: A Narrative Reviews. Iranian Journal of Nursing and Midwifery Research, 2024; 29(3): 290-296, 2024.
8. BRASIL. (FEBRASGO). Federação Brasileira das Associações de Ginecologia e Obstetrícia. Depressão Pós-parto. 2020. Disponível em: https ://www.febrasgo.org.br/media/k2/attachments/EdioZWebZAtualiz ada.pdf. Acessado em: 10 de fevereiro de 2025.
9. BRASIL. (FEBRASGO). Federação Brasileira das Associações de Ginecologia e Obstetrícia. Depressão Pós-parto. 2021. Disponível em: https ://sogirgs.org.br/area-do-associado/Depressao-Pos-parto-2021 .pdf. Acessado em: 10 de fevereiro de 2025.
10. BRASIL. MINISTÉRIO DA SAÚDE. Depressão pós-parto. 2022. Disponível em: https ://www.gov.br/s aude/pt-br/assuntos/saude-de-a-a-z/d/depressao-pos-parto. Acessado em: 10 de fevereiro de 2025.
11. CENTENO LO, et al. Is Serum Vitamin D Associated with Depression or Anxiety in Ante-and Postnatal Adult Women? A Systematic Review with Meta-Analysis. Nutrients, 2024; 16(21): 3648.
12. CIOBANU AM, et al. Severe vitamin D deficiency—a possible cause of resistance to treatment in psychiatric pathology. Medicina, 2023; 59(12): 2056.
13. CORSELLO A, et al. Vitamin D in pediatric age: Current evidence, recommendations, and misunderstandings. Frontiers in medicine, 2023; 10: 1107855.
14. DE SOUSA MN, et al. Trilhando o caminho do conhecimento: o método de revisão integrativa para análise e síntese da literatura científica. Observatorio de la economía latinoamericana, 2023; 21(10): 18448-18483.
15. DOMACASSÉ D, et al. Associations between Early-pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms. Psychosomatic Medicine, 2024; 10: 1097.
16. EID A, et al. Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD). Metabolic Brain Disease, 2019; 34: 1781-1786.
17. EYLES DW. Vitamin D: Brain and behavior. Journal of Bone and Mineral Research Plus, 2021; 5(1): 10419.
18. FAZELIAN S, et al. Effect of vitamin D supplement on mood status and inflammation in vitamin D deficient type 2 diabetic women with anxiety: a randomized clinical trial. International journal of preventive medicine, 2019; 10(1): 17.
19. FERNANDES-MOLL M, et al. Ocurrencia y factores asociados con la depresión posparto en un área urbana de Brasil. Enfermería Global, 2023; 22(69): 134-166.
20. GHAEDRAHMATI M e ALIPOUR Z. The Association Between Post-Partum Depression and Nutrition and Dietary Patterns: Systematic Review. Iranian Journal of Nursing and Midwifery Research, 2024; 29(3): 280-289.
21. GOULD JF, et al. A systematic review of vitamin D during pregnancy and postnatally and symptoms of depression in the antenatal and postpartum period from randomized controlled trials and observational studies. Nutrients, 2022; 14(11): 2300.
22. HOLLINSHEAD VR, et al. Low Vitamin D Concentration Is Associated with Increased Depression Risk in Adults 20–44 Years Old, an NHANES 2007–2018 Data Analysis with a Focus on Perinatal and Breastfeeding Status. Nutrients, 2024; 16(12): 1876, 2024.
23. LIN T, et al. Causal associations between vitamin D and postpartum depression: A bidirectional mendelian randomization study. Heliyon, 2024; 10(13).
24. MAEDA SS, et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Consenso, 2014; 412-414.
25. NOSHIRO K, et al. Association between Edinburgh postnatal depression scale and serum levels of ketone bodies and vitamin D, thyroid function, and iron metabolism. Nutrients, 2023; 15(3): 768.
26. RIBAMAR A, et al. Relação entre deficiência de vitamina D e depressão gestacional e pós parto. Nutrición Hospitalaria, 2020; 1238-1245.
27. RICHARD A, et al. Prevalence of vitamin D deficiency and its associations with skin color in pregnant women in the first trimester in a sample from Switzerland. Nutrients, 2017; 9(3): 260.
28. ROUHI M, et al. Vitamin D reduces postpartum depression and fatigue among Iranian women. British Journal of Midwifery, 2018; 26(12): 787-793.
29. SHUB A e MCCARTHY EA. Eficácia do programa de triagem e tratamento pré-natal para deficiência de vitamina D: um ensaio de campo randomizado estratificado. The Journal of Clinical Endocrinology & Metabolism, 2019; 104(2): 337-338.
30. SZPUNAR MJ. Association of antepartum vitamin D deficiency with postpartum depression: A clinical perspective. Public Health Nutrition, 2020; 7: 1173-1178.
31. TRUJILLO J, et al. A systematic review of the associations between maternal nutritional biomarkers and depression and/or anxiety during pregnancy and postpartum. Journal of affective disorders, 2018; 232: 185-203.
32. VAZIRI F, et al. A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. BMC pregnancy and childbirth, 2016; 16: 1-12.
33. WANG J, et al. Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies. Archives of gynecology and obstetrics, 2018; 298: 1045-1059.
34. YUAN Y, et al. The Association between Vitamin D Deficiency and Perinatal Depression: A Systematic Review and Meta-Analysis. Alpha Psychiatry, 2024; 6: 669.
35. ZEROFSKY MS, et al. Daily cholecalciferol supplementation during pregnancy alters markers of regulatory immunity, inflammation, and clinical outcomes in a randomized controlled trial. The Journal of Nutrition, 2016; 11: 2388-2397.
2. ACCORTT EE, et al. Low prenatal vitamin D metabolite ratio and subsequent postpartum depression risk. Journal of Women's Health, 2021; 30(1): 113-120.
3. ACCORTT EE, et al. Lower prenatal vitamin D status and postpartum depressive symptomatology in African American women: Preliminary evidence for moderation by inflammatory cytokines. Archives of women's mental health, 2016; 19(2): 373-383.
4. ACCORTT EE, et al. Vitamin D deficiency and depressive symptoms in pregnancy are associated with adverse perinatal outcomes. Journal of Behavioral Medicine, 2018; 41(5): 680-689.
5. AGHAJAFARI F, et al. Vitamin D deficiency and antenatal and postpartum depression: a systematic review. Nutrients, 2018; 10(4): 478.
6. AL-SABAH R, et al. Antenatal Depression and its Associated Factors: Findings from Kuwait Birth Cohort Study. Journal of epidemiology and global health, 2024; 14(3): 847-859.
7. BATEINEH S e ATOUM MF. Association between Vitamin D Levels During Pregnancy and Postpartum Depression: A Narrative Reviews. Iranian Journal of Nursing and Midwifery Research, 2024; 29(3): 290-296, 2024.
8. BRASIL. (FEBRASGO). Federação Brasileira das Associações de Ginecologia e Obstetrícia. Depressão Pós-parto. 2020. Disponível em: https ://www.febrasgo.org.br/media/k2/attachments/EdioZWebZAtualiz ada.pdf. Acessado em: 10 de fevereiro de 2025.
9. BRASIL. (FEBRASGO). Federação Brasileira das Associações de Ginecologia e Obstetrícia. Depressão Pós-parto. 2021. Disponível em: https ://sogirgs.org.br/area-do-associado/Depressao-Pos-parto-2021 .pdf. Acessado em: 10 de fevereiro de 2025.
10. BRASIL. MINISTÉRIO DA SAÚDE. Depressão pós-parto. 2022. Disponível em: https ://www.gov.br/s aude/pt-br/assuntos/saude-de-a-a-z/d/depressao-pos-parto. Acessado em: 10 de fevereiro de 2025.
11. CENTENO LO, et al. Is Serum Vitamin D Associated with Depression or Anxiety in Ante-and Postnatal Adult Women? A Systematic Review with Meta-Analysis. Nutrients, 2024; 16(21): 3648.
12. CIOBANU AM, et al. Severe vitamin D deficiency—a possible cause of resistance to treatment in psychiatric pathology. Medicina, 2023; 59(12): 2056.
13. CORSELLO A, et al. Vitamin D in pediatric age: Current evidence, recommendations, and misunderstandings. Frontiers in medicine, 2023; 10: 1107855.
14. DE SOUSA MN, et al. Trilhando o caminho do conhecimento: o método de revisão integrativa para análise e síntese da literatura científica. Observatorio de la economía latinoamericana, 2023; 21(10): 18448-18483.
15. DOMACASSÉ D, et al. Associations between Early-pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms. Psychosomatic Medicine, 2024; 10: 1097.
16. EID A, et al. Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD). Metabolic Brain Disease, 2019; 34: 1781-1786.
17. EYLES DW. Vitamin D: Brain and behavior. Journal of Bone and Mineral Research Plus, 2021; 5(1): 10419.
18. FAZELIAN S, et al. Effect of vitamin D supplement on mood status and inflammation in vitamin D deficient type 2 diabetic women with anxiety: a randomized clinical trial. International journal of preventive medicine, 2019; 10(1): 17.
19. FERNANDES-MOLL M, et al. Ocurrencia y factores asociados con la depresión posparto en un área urbana de Brasil. Enfermería Global, 2023; 22(69): 134-166.
20. GHAEDRAHMATI M e ALIPOUR Z. The Association Between Post-Partum Depression and Nutrition and Dietary Patterns: Systematic Review. Iranian Journal of Nursing and Midwifery Research, 2024; 29(3): 280-289.
21. GOULD JF, et al. A systematic review of vitamin D during pregnancy and postnatally and symptoms of depression in the antenatal and postpartum period from randomized controlled trials and observational studies. Nutrients, 2022; 14(11): 2300.
22. HOLLINSHEAD VR, et al. Low Vitamin D Concentration Is Associated with Increased Depression Risk in Adults 20–44 Years Old, an NHANES 2007–2018 Data Analysis with a Focus on Perinatal and Breastfeeding Status. Nutrients, 2024; 16(12): 1876, 2024.
23. LIN T, et al. Causal associations between vitamin D and postpartum depression: A bidirectional mendelian randomization study. Heliyon, 2024; 10(13).
24. MAEDA SS, et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. Consenso, 2014; 412-414.
25. NOSHIRO K, et al. Association between Edinburgh postnatal depression scale and serum levels of ketone bodies and vitamin D, thyroid function, and iron metabolism. Nutrients, 2023; 15(3): 768.
26. RIBAMAR A, et al. Relação entre deficiência de vitamina D e depressão gestacional e pós parto. Nutrición Hospitalaria, 2020; 1238-1245.
27. RICHARD A, et al. Prevalence of vitamin D deficiency and its associations with skin color in pregnant women in the first trimester in a sample from Switzerland. Nutrients, 2017; 9(3): 260.
28. ROUHI M, et al. Vitamin D reduces postpartum depression and fatigue among Iranian women. British Journal of Midwifery, 2018; 26(12): 787-793.
29. SHUB A e MCCARTHY EA. Eficácia do programa de triagem e tratamento pré-natal para deficiência de vitamina D: um ensaio de campo randomizado estratificado. The Journal of Clinical Endocrinology & Metabolism, 2019; 104(2): 337-338.
30. SZPUNAR MJ. Association of antepartum vitamin D deficiency with postpartum depression: A clinical perspective. Public Health Nutrition, 2020; 7: 1173-1178.
31. TRUJILLO J, et al. A systematic review of the associations between maternal nutritional biomarkers and depression and/or anxiety during pregnancy and postpartum. Journal of affective disorders, 2018; 232: 185-203.
32. VAZIRI F, et al. A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. BMC pregnancy and childbirth, 2016; 16: 1-12.
33. WANG J, et al. Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies. Archives of gynecology and obstetrics, 2018; 298: 1045-1059.
34. YUAN Y, et al. The Association between Vitamin D Deficiency and Perinatal Depression: A Systematic Review and Meta-Analysis. Alpha Psychiatry, 2024; 6: 669.
35. ZEROFSKY MS, et al. Daily cholecalciferol supplementation during pregnancy alters markers of regulatory immunity, inflammation, and clinical outcomes in a randomized controlled trial. The Journal of Nutrition, 2016; 11: 2388-2397.