Polimorfismos na interleucina-1B e sua influência em doenças associadas à infecção por Helicobacter pylori
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Aug 22, 2025
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Resumo
Objetivo: Analisar a associação entre polimorfismos na interleucina-1B (IL1B) e a suscetibilidade à infecção por Helicobacter pylori, considerando sua influência sobre a resposta inflamatória do hospedeiro, por meio de uma revisão integrative da literatura. Métodos: Foram incluídos estudos observacionais publicados entre 2003 e 2025, nos idiomas português e inglês, que abordassem a associação entre IL1B e H. pylori. Após triagem e aplicação dos critérios de elegibilidade, os artigos selecionados foram analisados qualitativamente. Resultados: Foram identificados 571 artigos, com exclusão de 263 por duplicidade. Após análise de 307 títulos e resumos, 109 artigos foram lidos na íntegra e 22 foram incluídos na revisão. Destes, 12 abordaram o polimorfismo IL1B-31, 16 o IL1B-511 e 8 o IL1B+3954. A técnica PCR-RFLP foi a mais empregada na genotipagem dos SNPs. Os principais achados indicaram associação do alelo IL1B-31 C e do genótipo CC, bem como do alelo IL1B-511 T com maior suscetibilidade à infecção. Considerações finais: Identificar polimorfismos na IL1B pode contribuir para o rastreamento de indivíduos com risco aumentado para infecção por H. pylori. Os achados reforçam o papel da genética na resposta inflamatória e no prognóstico clínico.
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Como Citar
SouzaJ. A., DutraH. C. de O. S., CostaC. C. P. da, SantosR. da S., & BarbosaM. S. (2025). Polimorfismos na interleucina-1B e sua influência em doenças associadas à infecção por Helicobacter pylori. Revista Eletrônica Acervo Saúde, 25(8), e20921. https://doi.org/10.25248/reas.e20921.2025
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Referências
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12. HELLMIG S, et al. Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer. Immunology Letters, 2005; 100(2): 107-112.
13. HNATYSZYN A, et al. DNA variants in Helicobacter pylori infected patients with chronic gastritis, dysplasia and gastric cancer. Advances In Medical Sciences, 2019; 64(1): 79-84.
14. HNATYSZYN A, et al. Interleukin-1 Gene Polymorphisms in Chronic Gastritis Patients Infected with Helicobacter pylori as Risk Factors of Gastric Cancer Development. Archivum Immunologiae et Therapiae Experimentalis, 2013; 61(6): 503-512.
15. KODAMAN N, et al. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proceedings of The National Academy of Sciences, 2014; 111(4): 1455-1460.
16. KULMAMBETOVA GN, et al. Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population. Asian Pacific Journal of Cancer Prevention, 2014; 15(18): 7763-7768.
17. KUMAR S, et al. Evidences showing association of interleukin-1B polymorphisms with increased risk of gastric cancer in an Indian population. Biochemical And Biophysical Research Communications, 2009; 387(3): 456-460.
18. LEMOS JR, et al. Genes de virulência e polimorfismos gênicos ligados à suscetibilidade à infecção por Helicobacter pylori. Saúde em Revista, 2020; 20(52): 119-130.
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21. NETO A, et al. Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori. Journal Of Venomous Animals and Toxins Including Tropical Diseases, 2014; 20(1): 17.
22. ÖZTEKIN M, et al. Overview of Helicobacter pylori Infection: clinical features, treatment, and nutritional aspects. Diseases, 2021; 9(4): 66.
23. PANIC N, et al. Susceptibility to Helicobacter pylori infection: results of an epidemiological investigation among gastric cancer patients. Molecular Biology Reports, 2014; 41(6): 3637-3650.
24. RAMIS IB, et al. Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis. The Journal of Infection in Developing Countries, 2015; 9(10): 1108-1116.
25. RAZA Y, et al. Combination of Interleukin 1 Polymorphism and Helicobacter pylori Infection: an increased risk of gastric cancer in pakistani population. Pathology & Oncology Research, 2017; 23(4): 873-880.
26. RECH TF, et al. Analysis of the Influence of Interleukin-1β Gene Polymorphism on Gastric Inflammatory Response and Precancerous Lesions Development in Patients with Functional Dyspepsia. Immunological Investigations, 2020; 49(5): 585-596.
27. SHAH SC, et al. Host Genetic Determinants Associated with Helicobacter pylori Eradication Treatment Failure: A Systematic Review and Meta-Analysis. Gastroenterology, 2021; 161(5): 21-22.
28. SHARNDAMA HC, et al. Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms. Brazilian Journal of Microbiology, 2022; 53(1): 33-50.
29. SICINSCHI LA, et al. Gastric cancer risk in a Mexican population: role of Helicobacter pylori cagA positive infection and polymorphisms in interleukin 1 and 10 genes. International Journal of Cancer, 2005; 118(3): 649-657.
30. SOUZA M, et al. Integrative review: what is it? how to do it? Einstein (São Paulo), 2010; 8(1): 102-106.
31. TANIGUCHI K e KARIN M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Seminars In Immunology, 2014; 26(1): 54-74.
32. XU W, et al. Relationship between Helicobacter pylori infection and gastrointestinal microecology. Frontiers In Cellular and Infection Microbiology, 2022; 12.
33. ZENG ZR, et al. Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China. Gut, 2003; 52(12): 1684-1689.
2. BARAKAT SH, et al. Interleukin-1β and Interleukin-1 receptor antagonist gene polymorphism in pediatric patients with Helicobacter pylori-associated chronic gastritis. Journal Of Tropical Pediatrics, 2021; 67(3).
3. BARBOZA MMO, et al. Contribution of genetic polymorphisms of interleukins IL1B-511 C/T, IL1RN VNTR, IL6-174 G/C, and IL8-251 A/T in gastric lesions: gender and Helicobacter pylori genes matter. Archives Of Microbiology, 2021; 203(6): 3467-3472.
4. CHANG YW, et al. Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer. International Journal of Cancer, 2004; 114(3): 465-471.
5. CHEN B, et al. Correlation Between Interleukin-1β-511 C/T Polymorphism and Gastric Cancer in Chinese Populations: a meta-analysis. Medical Science Monitor, 2016; 22: 1742-1750.
6. CON S, et al. Role of bacterial and genetic factors in gastric cancer in Costa Rica. World Journal of Gastroenterology, 2009; 15(2): 211.
7. CORREA P. A human model of gastric carcinogenesis. Cancer Res, 1988; 48(13): 3554-60.
8. EL FILALY H, et al. IL-1 Polymorphism and Helicobacter pylori Infection Features: Highlighting VNTR’s Potential in Predicting the Susceptibility to Infection-Associated Disease Development. Microorganisms, 2023; 11(2): 353.
9. EL-OMAR EM, et al. Genetic Predisposition for Helicobacter pylori Infection—The Jury Is Still Out! Gastroenterology, 2022; 162(6): 1591-1593.
10. FERLAY J, et al. Observatório Global do Câncer: Câncer Hoje. Lyon, França: Agência Internacional de Pesquisa sobre o Câncer, 2020.
11. HE BS, et al. Polymorphisms in Interleukin-1B (IL-1B) and Interleukin 1 Receptor Antagonist (IL-1RN) Genes Associate with Gastric Cancer Risk in the Chinese Population. Digestive Diseases and Sciences, 2011; 56(7): 2017-2023.
12. HELLMIG S, et al. Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer. Immunology Letters, 2005; 100(2): 107-112.
13. HNATYSZYN A, et al. DNA variants in Helicobacter pylori infected patients with chronic gastritis, dysplasia and gastric cancer. Advances In Medical Sciences, 2019; 64(1): 79-84.
14. HNATYSZYN A, et al. Interleukin-1 Gene Polymorphisms in Chronic Gastritis Patients Infected with Helicobacter pylori as Risk Factors of Gastric Cancer Development. Archivum Immunologiae et Therapiae Experimentalis, 2013; 61(6): 503-512.
15. KODAMAN N, et al. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proceedings of The National Academy of Sciences, 2014; 111(4): 1455-1460.
16. KULMAMBETOVA GN, et al. Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population. Asian Pacific Journal of Cancer Prevention, 2014; 15(18): 7763-7768.
17. KUMAR S, et al. Evidences showing association of interleukin-1B polymorphisms with increased risk of gastric cancer in an Indian population. Biochemical And Biophysical Research Communications, 2009; 387(3): 456-460.
18. LEMOS JR, et al. Genes de virulência e polimorfismos gênicos ligados à suscetibilidade à infecção por Helicobacter pylori. Saúde em Revista, 2020; 20(52): 119-130.
19. LI C, et al. Association between interleukin‐1 gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in a Chinese population. Journal Of Gastroenterology and Hepatology, 2007; 22(2): 234-239.
20. MA J, et al. Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: a meta-analysis. Plos One, 2017; 12(4).
21. NETO A, et al. Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori. Journal Of Venomous Animals and Toxins Including Tropical Diseases, 2014; 20(1): 17.
22. ÖZTEKIN M, et al. Overview of Helicobacter pylori Infection: clinical features, treatment, and nutritional aspects. Diseases, 2021; 9(4): 66.
23. PANIC N, et al. Susceptibility to Helicobacter pylori infection: results of an epidemiological investigation among gastric cancer patients. Molecular Biology Reports, 2014; 41(6): 3637-3650.
24. RAMIS IB, et al. Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis. The Journal of Infection in Developing Countries, 2015; 9(10): 1108-1116.
25. RAZA Y, et al. Combination of Interleukin 1 Polymorphism and Helicobacter pylori Infection: an increased risk of gastric cancer in pakistani population. Pathology & Oncology Research, 2017; 23(4): 873-880.
26. RECH TF, et al. Analysis of the Influence of Interleukin-1β Gene Polymorphism on Gastric Inflammatory Response and Precancerous Lesions Development in Patients with Functional Dyspepsia. Immunological Investigations, 2020; 49(5): 585-596.
27. SHAH SC, et al. Host Genetic Determinants Associated with Helicobacter pylori Eradication Treatment Failure: A Systematic Review and Meta-Analysis. Gastroenterology, 2021; 161(5): 21-22.
28. SHARNDAMA HC, et al. Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms. Brazilian Journal of Microbiology, 2022; 53(1): 33-50.
29. SICINSCHI LA, et al. Gastric cancer risk in a Mexican population: role of Helicobacter pylori cagA positive infection and polymorphisms in interleukin 1 and 10 genes. International Journal of Cancer, 2005; 118(3): 649-657.
30. SOUZA M, et al. Integrative review: what is it? how to do it? Einstein (São Paulo), 2010; 8(1): 102-106.
31. TANIGUCHI K e KARIN M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Seminars In Immunology, 2014; 26(1): 54-74.
32. XU W, et al. Relationship between Helicobacter pylori infection and gastrointestinal microecology. Frontiers In Cellular and Infection Microbiology, 2022; 12.
33. ZENG ZR, et al. Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China. Gut, 2003; 52(12): 1684-1689.