Ataxia em pacientes com tremor distônico
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Resumo
Objetivo: Reunir evidências científicas disponíveis sobre ataxia em pacientes com tremor distônico. Métodos: Trata-se de uma revisão integrativa. Foram utilizadas as seguintes bases de dados: Medline (via PubMed), Embase e Web of Science. Além disso, foi realizada uma busca secundária na lista de referências dos estudos incluídos e na literatura cinzenta. Os critérios de elegibilidade foram artigos que descrevessem pacientes com diagnóstico de tremor distônico e ataxia. Resultados: Foram identificados 105 estudos, dos quais 18 estudos foram incluídos. Doze dos estudos são relatos de caso e seis são séries de casos, com uma amostra total de 27 pacientes. O tremor distônico em membros superiores esteve presente em quase 80% dos pacientes, seguido pelo tremor distônico de cabeça (33,3%) e tremor distônico de pescoço e membros inferiores (14,8%). Diversos tipos de ataxias foram identificados. Considerações finais: A ataxia cerebelar é uma condição neurológica com heterogeneidade clínica que pode ser identificada concomitantemente com o tremor distônico. O tremor distônico pode ser o sintoma inicial de apresentação. Vários genes são responsáveis pela ataxia; no entanto, estudos observacionais adicionais são necessários para estabelecer uma associação entre ataxia e tremor distônico.
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