Complications of chagasic cardiomyopathy in young adult patient

Abstract

Objective: To analyze the evolution of Chagasic cardiomyopathy in young adult patients, identifying in the literature the main complications and the most current diagnostic and therapeutic approaches. Methods: Integrative literature review in five main databases for research. The inclusion criteria were Portuguese, English and Spanish; articles published between 2010 to 2020, with descriptors chagasic cardiomyopathy and complications. Results: 184 articles were found and nine were included, namely: case control (1), cross-sectional studies (2), reviews (4), randomized clinical trials (1) and retrospective cohort (1). Diagnostic exams such as serology for Trypanossoma Cruzi, electrocardiogram and magnetic resonance were relevant for the follow-up of patients with Chagasic Cardiomyopathy. As therapeutic options, heart transplant and bone marrow cell transplant showed suitable results; in contrast, drug therapy with benznidazole did not show any benefit in chronic Chagas Heart Disease with specific organ damage. Final considerations: Findings indicate that there are treatments that could assist in such complications, such as heart transplantation and bone marrow cell therapy. The scarcity of studies shows the need for further researches to develop more effective therapies to improve the survival of these patients.