Study of neuroanatomical sequelae associated with Post-COVID-19 Syndrome

Abstract

Objective: To address the pathophysiology of SARS-CoV-2 infection and describe the neuroanatomical repercussions triggered by Post-COVID Syndrome. Bibliographic review: COVID-19 is an acute viral respiratory disease. SARS-CoV-2 is a ꞵ-coronavirus with RNA-like genetic material with the surface encrusted with spike (S) proteins that allow the pathogen to enter the cell. Clinical manifestations are related to the host's immune response and are characterized by involvement in various organs and systems. Neurological repercussions can be non-specific, moderate and severe. Post-COVID syndrome 19 is the set of clinical manifestations that persist for more than two or three weeks after the onset of symptoms. Among the associated affections, neuroanatomical sequelae stand out as injuries capable of causing significant morbidity and mortality. As this is an incipient condition, there is still no standard treatment instituted to manage these sequelae. Final considerations: Post-COVID Syndrome 19 is associated with important sequelae, including in the Central Nervous System. Different neurological manifestations were described, such as encephalopathy, stroke, anosmia, ageusia, dizziness, headache, Guillain-Barré syndrome, among others. It is necessary to conduct more studies so that the management of these patients is supported by the best evidence in order to minimize long-term morbidities.